SOBETIROME
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- CAS号:
- 211110-63-3
- 英文名:
- QRX 431
- 英文别名:
- GC-1;NET44;EIEE3;QRX 431;Anti-GC1;Anti-OlfD;SobetiroMe;Anti-GW112;Anti-NET44;Anti-KIAA4294
- 中文名:
- SOBETIROME
- 中文别名:
- 索贝罗姆;化合物SOBETIROME;2-(4-(4-羟基-3-异丙基苄基)-3,5-二甲基苯氧基)乙酸
- CBNumber:
- CB22628338
- 分子式:
- C20H24O4
- 分子量:
- 328.4
- MOL File:
- 211110-63-3.mol
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SOBETIROME化学性质
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熔点:
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122 - 124°C
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沸点:
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510.2±45.0 °C(Predicted)
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密度:
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1.152±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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3.22±0.10(Predicted)
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形态:
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powder
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颜色:
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white to beige
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InChIKey:
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QNAZTOHXCZPOSA-UHFFFAOYSA-N
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SOBETIROME性质、用途与生产工艺
Sobetirome (GC-1) 是一种甲状腺激素受体 β (TRβ) 激动剂，Sobetirome可选择性结合到TRβ-1，EC50 为 0.16 μM。
EC50: 0.16 μM (TRβ-1), 0.58 μM (TRα-1)
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20% (1.3 g).
SOBETIROME
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-14823 | Sobetirome | | 1 mg | 500元 |
| 2024/08/19 | HY-14823 | SOBETIROME
Sobetirome | 211110-63-3 | 5mg | 1100元 |
211110-63-3, SOBETIROME 相关搜索:
- 抑制剂
- 索贝罗姆
- 2-(4-(4-羟基-3-异丙基苄基)-3,5-二甲基苯氧基)乙酸
- 化合物SOBETIROME
- 211110-63-3
- QRX431,Inhibitor,GC1,Sobetirome,inhibit,QRX 431,Thyroid Hormone Receptor,GC-1,GC 1,THR
- GC-1; QRX-431
- 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
- GC-1 (Sobetirome)
- Acetic acid, 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-
- Sobetirome >=98% (HPLC)
- Anti-NET44
- Anti-GC1
- Anti-FLJ13044
- Anti-OlfD
- Anti-Olfactomedin 4
- Anti-KIAA4294
- Anti-GW112
- Anti-bA209J19.1
- Anti-SLC25A22, (N-terminal) antibody produced in rabbit
- NET44
- EIEE3
- Anti-SLC25A22 antibody produced in rabbit
- 2-(4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid
- GC 1 (pharmaceutical)
- [3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]acetic acid
- SobetiroMe
- GC-1
- QRX 431
- [4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid
- Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22