1236287-04-9
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- CAS号:
- 1236287-04-9
- 英文名:
- Tenofovir (Maleate)
- 英文别名:
- Tenofovir (Maleate)
- 中文名:
- 1236287-04-9
- 中文别名:
- 替诺福韦马来酸盐;化合物 T21775
- CBNumber:
- CB22677048
- 分子式:
- C13H18N5O8P
- 分子量:
- 403.29
- MOL File:
- 1236287-04-9.mol
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1236287-04-9化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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1236287-04-9性质、用途与生产工艺
Tenofovir maleate (GS 1278 maleate) 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂,有潜力用于艾滋病毒和慢性乙型肝炎的研究。
Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC
50
values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage. Tenofovir and M48U1 formulated in 0.25% HEC each inhibits the replication of both R5-tropic HIV-1
BaL
and X4-tropic HIV-1
IIIb
in activated PBMCs, and inhibits several laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% HEC exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1
BaL
, and is not toxic to PBMCs.
Tenofovir Disoproxil Fumarate (20, 50, 140, or 300 mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300 mg/kg) significantly reduces HIV transmission in BLT mice. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection.
1236287-04-9
上下游产品信息
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下游产品
1236287-04-9, 1236287-04-9 相关搜索:
- 化合物 T21775
- 替诺福韦马来酸盐
- 1236287-04-9
- Tenofovir (Maleate)