666179-74-4
|
|
- CAS号:
- 666179-74-4
- 英文名:
- Risperidone (hydrochloride)
- 英文别名:
- Risperidone (hydrochloride);3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
- 中文名:
- 666179-74-4
- 中文别名:
- 利哌酮盐酸盐;化合物 RISPERIDONE HYDROCHLORIDE
- CBNumber:
- CB22677073
- 分子式:
- C23H28ClFN4O2
- 分子量:
- 446.9454232
- MOL File:
- 666179-74-4.mol
|
|
|
666179-74-4化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Powder
-
|
666179-74-4性质、用途与生产工艺
Risperidone hydrochloride (R 64 766 hydrochloride) 是 5-HT2 受体的阻断剂,P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8,5.9 nM。
5-HT
2
Receptor
4.8 nM (Ki)
|
dopamine D
2
receptor
5.9 nM (Ki)
|
P-Glycoprotein
|
Risperidone is a serotonin 5-HT
2
receptor blocker, P-Glycoprotein inhibitor and potent dopamine D
2
receptor antagonist, with K
i
s of 4.8, 5.9 nM for 5-HT
2A
and dopamine D
2
receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs.
In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner.
666179-74-4
上下游产品信息
上游原料
下游产品
666179-74-4, 666179-74-4 相关搜索:
- 抑制剂
- C23H28ClFN4O2
- 化合物 RISPERIDONE HYDROCHLORIDE
- 利哌酮盐酸盐
- 666179-74-4
- 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
- Risperidone (hydrochloride)