他莫昔芬EP杂质F
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- CAS号:
- 31750-48-8
- 英文名:
- N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
- 英文别名:
- ici55,548;desmethyltamoxifen;n-desmethyltamoxifen;Tamoxifen EP Impurity F;N-DESMETHYL TAMOXIFEN HCL;tamoxifen citrate impurity F;N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE;N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
- 中文名:
- 他莫昔芬EP杂质F
- 中文别名:
- 去甲基他莫昔芬;他莫昔芬EP杂质F;枸橼酸他莫昔芬EP杂质F;柠檬酸他莫昔芬EP杂质F;枸橼酸他莫昔芬杂质6 单体 (枸橼酸他莫昔芬EP杂质F);(Z)-2-(4-(1,2-二苯基丁-1-烯-1-基)苯氧基)-N-甲基乙胺;2-[4-[(1Z)-1,2-二苯基-1-丁烯-1-基]苯氧基]-N-甲基-乙胺
- CBNumber:
- CB2267847
- 分子式:
- C25H27NO
- 分子量:
- 357.49
- MOL File:
- 31750-48-8.mol
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他莫昔芬EP杂质F化学性质
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沸点:
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485.8±33.0 °C(Predicted)
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密度:
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1.047±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM)
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酸度系数(pKa):
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9.38±0.10(Predicted)
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水溶解性:
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Water: Insoluble
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他莫昔芬EP杂质F性质、用途与生产工艺
N-Desmethyltamoxifen 是 Tamoxifen 在人体内的主要代谢产物。N-Desmethyltamoxifen,较弱的抗雌激素,是一种比 Tamoxifen 强十倍的蛋白激酶 C (PKC) 抑制剂。N-Desmethyltamoxifen 也是人体 AML 细胞神经酰胺代谢的有效调节因子,限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
N-desmethyltamoxifen (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
Cell Line:
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MCF 7 human mammary carcinoma cells
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Concentration:
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1.5, 2.5, 5, 7.5, 10 μM
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Incubation Time:
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114 hours
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Result:
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Inhibits growth of MCF 7 human mammary carcinoma cells
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他莫昔芬EP杂质F
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-129099A | N-Desmethyltamoxifen hydrochloride | | 1 mg | 450元 |
2024/08/19 | HY-129099A | 他莫昔芬EP杂质F N-Desmethyltamoxifen hydrochloride | 31750-48-8 | 5mg | 900元 |
31750-48-8, 他莫昔芬EP杂质F 相关搜索:
- 枸橼酸他莫昔芬杂质6 单体 (枸橼酸他莫昔芬EP杂质F)
- (Z)-2-(4-(1,2-二苯基丁-1-烯-1-基)苯氧基)-N-甲基乙胺
- 2-[4-[(1Z)-1,2-二苯基-1-丁烯-1-基]苯氧基]-N-甲基-乙胺
- 枸橼酸他莫昔芬EP杂质F
- 柠檬酸他莫昔芬EP杂质F
- 去甲基他莫昔芬
- 他莫昔芬EP杂质F
- 31750-48-8
- 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methyl-ethanamine
- tamoxifen citrate impurity F
- (Z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine
- Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-
- n-desmethyltamoxifen
- ici55,548
- desmethyltamoxifen
- cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine
- 2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin
- 2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin
- N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE
- N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
- N-DESMETHYL TAMOXIFEN HCL
- 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl
- Tamoxifen EP Impurity F
- (Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE