3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
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- CAS号:
- 2003260-55-5
- 英文名:
- Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- 英文别名:
- CS-2874;KDM4B-IN-B3;NCGC00244536;KDM4B Inhibitor B3;NCGC00244536(Benzamide);KDM4B INHIBITOR COMPOUND B3;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide;Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-;NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
- 中文名:
- 3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
- 中文别名:
- 化合物NCGC00244536;3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
- CBNumber:
- CB23146688
- 分子式:
- C25H22N2O2
- 分子量:
- 382.45
- MOL File:
- 2003260-55-5.mol
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3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺化学性质
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沸点:
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646.9±55.0 °C(Predicted)
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密度:
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1?+-.0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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4.81±0.40(Predicted)
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颜色:
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Light yellow to green yellow
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3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺性质、用途与生产工艺
NCGC00244536是高效的 KDM4B 抑制剂，IC50 值为10 nM。
NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC
50
=40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC
50
s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC
50
s.
Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.
3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101799 | 3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
NCGC00244536 | 2003260-55-5 | 1mg | 1100元 |
| 2024/11/08 | HY-101799 | 3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
NCGC00244536 | 2003260-55-5 | 10mM * 1mLin DMSO | 2777元 |
3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
生产厂家
2003260-55-5, 3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺 相关搜索:
- 抑制剂
- 生物试剂
- 对照品
- 化合物NCGC00244536
- 3-(8-羟基喹啉-6-基)-N-(3-苯基丙基)苯甲酰胺
- 2003260-55-5
- NCGC00244536(Benzamide)
- 3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide
- NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
- KDM4B Inhibitor B3
- KDM4B-IN-B3
- NCGC00244536
- Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- CS-2874
- KDM4B INHIBITOR COMPOUND B3