2018300-62-2
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- CAS号:
- 2018300-62-2
- 英文名:
- TPOP146
- 英文别名:
- TPOP146;TPOP-146; TPOP 146;7-(3,5-dimethoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-4-propanoyl-3,5-dihydro-2H-1,4-benzoxazepine-9-carboxamide;1,4-Benzoxazepine-9-carboxamide, 7-(3,5-dimethoxyphenyl)-2,3,4,5-tetrahydro-N-[(3S)-1-methyl-3-piperidinyl]-4-(1-oxopropyl)-
- 中文名:
- 2018300-62-2
- 中文别名:
- 化合物 T17147;CBP/P300苯并西泮溴结构域抑制剂(TPOP146)
- CBNumber:
- CB23171703
- 分子式:
- C27H35N3O5
- 分子量:
- 481.58
- MOL File:
- 2018300-62-2.mol
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2018300-62-2化学性质
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沸点:
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641.8±55.0 °C(Predicted)
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密度:
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1.24±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 100 mg/mL (207.65 mM)
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形态:
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Solid
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酸度系数(pKa):
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10.68±0.20(Predicted)
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颜色:
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White to off-white
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2018300-62-2性质、用途与生产工艺
TPOP146是选择性的CBP/P300苯并西泮溴结构域抑制剂；对CBP和BRD4的Kd值分别为134 nM和5.02 μM。
IC50: 134 nM (CBP); 5.02 μM (BRD4)
Exposure to 1 μM TPOP146 results in a significant decrease of recovery half-life that is comparable to the construct that contained the bromodomain inactivating mutation N1168F, demonstrating that TPOP146 targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments.
2018300-62-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100697 | TPOP146 | | 1 mg | 477元 |
| 2024/04/30 | HY-100697 | 2018300-62-2
TPOP146 | 2018300-62-2 | 5mg | 1050元 |
2018300-62-2, 2018300-62-2 相关搜索:
- 细胞生物学试剂
- 化合物 T17147
- CBP/P300苯并西泮溴结构域抑制剂(TPOP146)
- 2018300-62-2
- TPOP-146; TPOP 146
- 7-(3,5-dimethoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-4-propanoyl-3,5-dihydro-2H-1,4-benzoxazepine-9-carboxamide
- 1,4-Benzoxazepine-9-carboxamide, 7-(3,5-dimethoxyphenyl)-2,3,4,5-tetrahydro-N-[(3S)-1-methyl-3-piperidinyl]-4-(1-oxopropyl)-
- TPOP146