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149247-12-1

149247-12-1, 149247-12-1, 结构式
149247-12-1
CAS号:
149247-12-1
英文名:
3,4-Dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1(2H)-naphthalenone
英文别名:
QF0301B;QF0301B,QF-0301B;3,4-Dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1(2H)-naphthalenone;1(2H)-Naphthalenone, 3,4-dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
中文名:
149247-12-1
中文别名:
化合物 T10100
CBNumber:
CB23339578
分子式:
C23H28N2O2
分子量:
364.48062
MOL File:
149247-12-1.mol

149247-12-1化学性质

储存条件:
Store at -20°C
溶解度:
Soluble in DMSO
安全信息

149247-12-1性质、用途与生产工艺

生物活性

QF0301B是α1肾上腺素能受体 (α1 adrenergic receptor) 拮抗剂,也可阻断α2肾上腺素受体,5-HT2A和组胺H1受体。

靶点

IC50: Adrenergic receptor

体外研究

In isolated rubbed rat aorta rings, QF0301B shows marked α1-adrenoceptor blocking activity, with a pA2 value of 9.00±0.12. QF0301B reverses and competitively antagonizes the inhibitory action produced by clonidine in electrically stimulated rat vas deferens and inhibits the force and rate of contraction in rat isolated atria (pA2=5.91±0.43), competitively antagonizes the contractile effect of 5-HT in rat aorta (pA2=6.75±0.06) and in rat stomach fundus (pA2=7.13±0.48) and the contractions induced by histamine in isolated guinea pig longitudinal ileal muscle (pA2=7.40±0.40). QF0301B shows noncompetitive low action in 5-HT3, muscarinic and nicotinic receptors, or as Ca 2+ antagonist.

体内研究

QF0301B (0.1-0.2 mg/kg iv) can cause a pronounced and prolonged fall in mean arterial blood pressure accompanied by bradycardia. QF0301B does not significantly modify the cardiovascular effects of either 5-hydroxytryptamine (serotonin, 5-HT, 75 mg/kg iv) or the selective a2-adrenoceptor agonist B-HT 920 (0.2 mg/kg iv), but markedly inhibits the hypertensive effect of noradrenaline (5 mg/kg iv), a nonselective a-adrenergic receptor agonist.

149247-12-1 上下游产品信息

上游原料

下游产品


149247-12-1 生产厂家

全球有 6家供应商   149247-12-1国内生产厂家
供应商联系电话电子邮件国家产品数优势度
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn 美国 4863 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
BOC Sciences info@bocsci.com 美国 0 65
天津普西唐生物医药科技有限公司 010-60605840 psaitong@jm-bio.com 中国 29778 58
TargetMol中国(陶术生物) 4008200310 marketing@tsbiochem.com 中国 24017 58
 

149247-12-1, 149247-12-1 相关搜索:

  • 化合物 T10100
  • 149247-12-1
  • QF0301B,QF-0301B
  • 1(2H)-Naphthalenone, 3,4-dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
  • QF0301B
  • 3,4-Dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1(2H)-naphthalenone
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