149247-12-1
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- CAS号:
- 149247-12-1
- 英文名:
- 3,4-Dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1(2H)-naphthalenone
- 英文别名:
- QF0301B;QF0301B,QF-0301B;3,4-Dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1(2H)-naphthalenone;1(2H)-Naphthalenone, 3,4-dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
- 中文名:
- 149247-12-1
- 中文别名:
- 化合物 T10100
- CBNumber:
- CB23339578
- 分子式:
- C23H28N2O2
- 分子量:
- 364.48062
- MOL File:
- 149247-12-1.mol
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149247-12-1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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149247-12-1性质、用途与生产工艺
QF0301B是α1肾上腺素能受体 (α1 adrenergic receptor) 拮抗剂,也可阻断α2肾上腺素受体,5-HT2A和组胺H1受体。
IC50: Adrenergic receptor
In isolated rubbed rat aorta rings, QF0301B shows marked α1-adrenoceptor blocking activity, with a pA2 value of 9.00±0.12. QF0301B reverses and competitively antagonizes the inhibitory action produced by clonidine in electrically stimulated rat vas deferens and inhibits the force and rate of contraction in rat isolated atria (pA2=5.91±0.43), competitively antagonizes the contractile effect of 5-HT in rat aorta (pA2=6.75±0.06) and in rat stomach fundus (pA2=7.13±0.48) and the contractions induced by histamine in isolated guinea pig longitudinal ileal muscle (pA2=7.40±0.40). QF0301B shows noncompetitive low action in 5-HT3, muscarinic and nicotinic receptors, or as Ca
2+
antagonist.
QF0301B (0.1-0.2 mg/kg iv) can cause a pronounced and prolonged fall in mean arterial blood pressure accompanied by bradycardia. QF0301B does not significantly modify the cardiovascular effects of either 5-hydroxytryptamine (serotonin, 5-HT, 75 mg/kg iv) or the selective a2-adrenoceptor agonist B-HT 920 (0.2 mg/kg iv), but markedly inhibits the hypertensive effect of noradrenaline (5 mg/kg iv), a nonselective a-adrenergic receptor agonist.
149247-12-1
上下游产品信息
上游原料
下游产品
149247-12-1, 149247-12-1 相关搜索:
- 化合物 T10100
- 149247-12-1
- QF0301B,QF-0301B
- 1(2H)-Naphthalenone, 3,4-dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
- QF0301B
- 3,4-Dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1(2H)-naphthalenone