291778-77-3
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- CAS号:
- 291778-77-3
- 英文名:
- AE-3763
- 英文别名:
- AE-3763;1-Imidazolidineacetic acid, 3-[2-[[(1S)-2-methyl-1-[[(2S)-2-[[[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]propyl]amino]-2-oxoethyl]-2-oxo-
- 中文名:
- 291778-77-3
- 中文别名:
- 化合物 T10254
- CBNumber:
- CB24694528
- 分子式:
- C23H34F3N5O7
- 分子量:
- 549.54
- MOL File:
- 291778-77-3.mol
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291778-77-3化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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颜色:
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White to off-white
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291778-77-3性质、用途与生产工艺
AE-3763 是基于多肽的人中性粒细胞弹性蛋白酶 (human neutrophil elastase) 抑制剂，IC50 值为29 nM。
IC50: 29 nM (Human neutrophil elastase)
AE-3763 exhibits potent
in vitro
inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED
50
: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv.
291778-77-3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19406 | AE-3763 | | 1 mg | 5800元 |
| 2023/03/20 | HY-19406 | 291778-77-3
AE-3763 | 291778-77-3 | 5mg | 14500元 |
291778-77-3, 291778-77-3 相关搜索:
- 抑制剂
- C23H34F3N5O7
- 化合物 T10254
- 291778-77-3
- 1-Imidazolidineacetic acid, 3-[2-[[(1S)-2-methyl-1-[[(2S)-2-[[[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]propyl]amino]-2-oxoethyl]-2-oxo-
- AE-3763