BM635
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- CAS号:
- 1493762-74-5
- 英文名:
- BM635
- 英文别名:
- BM635;Morpholine, 4-[[1-(4-fluorophenyl)-2-methyl-5-[4-(1-methylethyl)phenyl]-1H-pyrrol-3-yl]methyl]-
- 中文名:
- BM635
- 中文别名:
- 化合物 T10563
- CBNumber:
- CB24796637
- 分子式:
- C25H29FN2O
- 分子量:
- 392.51
- MOL File:
- 1493762-74-5.mol
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BM635化学性质
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沸点:
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500.3±50.0 °C(Predicted)
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密度:
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1.12±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 31 mg/mL (78.98 mM)
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酸度系数(pKa):
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6.70±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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BM635性质、用途与生产工艺
BM635是 MmpL3 的抑制剂， 具有出色的抗分歧杆菌活性。抑制结合分歧杆菌H37Rv的MIC50 值为0.12 μM。
MIC50: 0.12 μM (M. tuberculosis H37Rv)
BM635 has potent MIC (0.12 µM), Tox
50
:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED
99
of 49 mg/Kg (IC
95%
: 43–54 mg/Kg). The half-life
in vivo
of BM635 is 1h, allowing a reasonable maximum concentration (C
max
=1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure
in vivo
.
BM635
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-109587 | BM635
BM635 | 1493762-74-5 | 1mg | 1100元 |
| 2024/04/30 | HY-109587 | BM635
BM635 | 1493762-74-5 | 10 mM * 1 mLin DMSO | 2850元 |
1493762-74-5, BM635 相关搜索:
- C25H29FN2O
- 化合物 T10563
- 1493762-74-5
- Morpholine, 4-[[1-(4-fluorophenyl)-2-methyl-5-[4-(1-methylethyl)phenyl]-1H-pyrrol-3-yl]methyl]-
- BM635