239440-20-1
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- CAS号:
- 239440-20-1
- 英文名:
- FR183998 free base
- 英文别名:
- FR183998;FR183998 free base;FR-183998 free base,FR183998 free base;1,3-Benzenedicarboxamide, N1-(aminoiminomethyl)-5-(2,5-dichloro-3-thienyl)-N3-[2-(dimethylamino)ethyl]-
- 中文名:
- 239440-20-1
- 中文别名:
- 化合物 T11319;化合物FR183998
- CBNumber:
- CB24797058
- 分子式:
- C17H19Cl2N5O2S
- 分子量:
- 428.34
- MOL File:
- 239440-20-1.mol
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239440-20-1化学性质
-
密度:
-
1.48±0.1 g/cm3(Predicted)
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-
储存条件:
-
Store at -20°C
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溶解度:
-
Soluble in DMSO
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-
形态:
-
Solid
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-
酸度系数(pKa):
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11.35±0.46(Predicted)
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颜色:
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White to off-white
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239440-20-1性质、用途与生产工艺
FR183998 free base 是一种有效的 Na+/H+-exchange 抑制剂,通过测量在大鼠淋巴细胞、血小板及人血小板 pHi 值的变化中,得到 IC50 值分别为 0.3 nM,6.5 nM 和 3.1 nM。
IC50: 0.3 nM (Na
+
/H
+
-exchange, Rat lymphocytes), 3.1 nM (Na
+
/H
+
-exchange, Human platelet), 6.5 nM (Na
+
/H
+
-exchange, Rat platelet)
FR183998 free base is a Na
+
/H
+
-exchange inhibitor, with IC
50
s of 0.3 nM, 6.5 nM and 3.1 nM by measurement of pH
i
change in rat lymphocytes, rat and human platelets, respectively.
FR183998 (0.1 and 1.0 mg/kg, i.v.) shows no effect hemodynamic parameters, and does not affect mean blood pressure and heart rate in conscious rats. Pretreatment of 0.01, 0.032, 0.10 mg/kg FR183998 or posttreament of 0.032 and 0.10 mg/kg FR183998 via intravenous administration, dose-dependently reuces reperfusion-induced ventricular fibrillation (VF) and mortality in reperfusion-induced arrhythmias in anesthetized rats, with ED
50
s against VF of 0.015 mg/kg and 0.070 mg/kg, respectively. FR183998 also reduces myocardial infarct sizes, and suppresses the arrhythmias in anesthetized rats. FR183998 (1 mg/kg, i.v.) reduces the increase in serum levels of alanine transaminase, aspartate transaminase, and lactate dehydrogenase induced by hepatic I/R, and prevents the incidences of hepatic necrosis, apoptosis, and neutrophil infiltration. FR183998 blocks the I/R-induced activation of the NF-κB, reduces induction of iNOS and inhibits the production of nitric oxide. FR183998 also decreases the expression of the iNOS gene antisense transcript in the liver of hepatic I/R rats.
239440-20-1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-100302 | 239440-20-1 FR183998 free base | 239440-20-1 | 1 mg | 4250元 |
2024/04/30 | HY-100302 | 239440-20-1 FR183998 free base | 239440-20-1 | 5 mg | 8500元 |
239440-20-1, 239440-20-1 相关搜索:
- 化合物FR183998
- 化合物 T11319
- 239440-20-1
- FR183998
- FR-183998 free base,FR183998 free base
- 1,3-Benzenedicarboxamide, N1-(aminoiminomethyl)-5-(2,5-dichloro-3-thienyl)-N3-[2-(dimethylamino)ethyl]-
- FR183998 free base