hydrochloride
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- CAS号:
- 446031-79-4
- 英文名:
- 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate monohydrochloride
- 英文别名:
- SSR180711;SR-180711;SSR180711A;SSR-180711;SSR-180711A;SSR-180711C;SSR-180711A HCl;SSR 180711 hydrochloride;SSR180711 hydrochloride,SSR-180711 hydrochloride;(4-bromophenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate
- 中文名:
- hydrochloride
- 中文别名:
- 化合物 T28856;SSR180711 盐酸盐
- CBNumber:
- CB24840518
- 分子式:
- C14H17BrN2O2.ClH
- 分子量:
- 361.66
- MOL File:
- 446031-79-4.mol
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hydrochloride化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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颜色:
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White to off-white
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hydrochloride性质、用途与生产工艺
SSR180711 hydrochloride 是具有口服活性，选择性和可逆的 α7 n-AChRs 部分激动剂。SSR180711 hydrochloride 可以作用于大鼠 α7 n-AChRs (Ki=22 nM；IC50=30 nM) 和人 α7 n-AChRs (Ki=14 nM；IC50=18 nM)。SSR180711 hydrochloride 增加海马区的谷氨酸能神经传递，Ach 释放和长时程增强 (LTP)。
IC50: 30 nM (rat α7 n-AChR) and 18 nM (human α7 n-AChR)
Ki: 22 nM (rat α7 n-AChR) and 14 nM (human α7 n-AChR)
SSR180711 hydrochloride is selective for the α7 receptor subtype compared to α4β2, α3β2, α3β4, and α1β1γδ human n-AChR subtypes (IC
50
>5 μM). SSR180711 hydrochloride (10 μM) has no inhibition (lower than 50%) for the ionic channels, neurotransmitter, or peptide receptors.
SSR180711 hydrochloride (0.01-10000 μM) is a potent partial agonist at human α7 n-AChRs expressed in Xenopus oocytes or GH4C1 cells and elicits typical concentration-dependent inward currents with an EC
50
value of 4.4 μM (2.5-7.8 μM).
SSR180711 hydrochloride rapidly penetrates into the brain (ID
50
=8 mg/kg; p.o.). SSR180711 hydrochloride dose-dependently inhibits the specific [
3H
]α-BTX binding in the mouse brain (ID
50
=8.3 and 7.5 mg/kg for p.o. and i.p., respectively).
SSR180711 hydrochloride (1-10 mg/kg for i.p.; 10-30 mg/kg for p.o.) dose-dependently increases extracellular acetylcholine (ACh) levels in the hippocampus and prefrontal cortex of freely moving rats.
SSR180711 hydrochloride (0.1, 0.3, 1 mg/kg; i.v.) dose-dependently increases firing rate.
hydrochloride
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-19411 | hydrochloride
SSR180711 hydrochloride | 446031-79-4 | 5mg | 750元 |
| 2024/08/19 | HY-19411 | hydrochloride
SSR180711 hydrochloride | 446031-79-4 | 10mM * 1mLin DMSO | 830元 |
446031-79-4, hydrochloride 相关搜索:
- 抑制剂
- C14H18BrClN2O2
- SSR180711 盐酸盐
- 化合物 T28856
- 446031-79-4
- SSR180711 hydrochloride,SSR-180711 hydrochloride
- SSR-180711C
- SSR-180711A HCl
- SSR-180711A
- SSR180711A
- SSR-180711
- SSR180711
- SR-180711
- SSR 180711 hydrochloride
- (4-bromophenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate