BMS-1166
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- CAS号:
- 1818314-88-3
- 英文名:
- BMS-1166
- 英文别名:
- BMS-1166;PD-1/PD-L1-IN1;BMS-1166 (PD-1/PD-L1-IN1);PD-1/PD-L1-IN1 BMS-1166;BMS-1166 (Synonyms: PD-1/PD-L1-IN1);BMS 1166Q: What is
BMS 1166 Q: What is the CAS Number of
BMS 1166;Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit;D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-;(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
- 中文名:
- BMS-1166
- 中文别名:
- 化合物BMS1166;(4R)-1-[[5-氯-2-[(3-氰基苯基)甲氧基]-4-[[3-(2,3-二氢-1,4-苯并二氧杂环己烷-6-基)-2-甲基苯基]甲氧基]苯基]甲基]-4-羟基-D-脯氨酸;(2R,4R)-1-(5-氯-2-((3-氰基苄基)氧基)-4-((3-(2,3-二氢苯并[B] [1,4]二氧杂环己烯-6-基)-2-甲基苄基)氧基)苄基)-4-羟基吡咯烷-2-羧酸
- CBNumber:
- CB24843928
- 分子式:
- C36H33ClN2O7
- 分子量:
- 641.11
- MOL File:
- 1818314-88-3.mol
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BMS-1166化学性质
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沸点:
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817.5±65.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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2.03±0.40(Predicted)
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颜色:
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White to off-white
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BMS-1166性质、用途与生产工艺
BMS-1166是新型有效的PD-1/PD-L1相互作用抑制剂,IC50为1.4 nM。
Target | Value |
PD-1/PD-L1 interaction
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1.4 nM
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BMS-1166对所检测的细胞系毒性作用低,阻止可溶性PD-L1与表达于细胞表面的PD-1受体的相互作用。BMS-1166可减轻PD-L1对T细胞受体介导的T淋巴细胞活化的抑制作用。
BMS-1166
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-102011 | BMS-1166 | | 1 mg | 963元 |
2024/08/19 | HY-102011 | BMS-1166 | | 5 mg | 2300元 |
1818314-88-3, BMS-1166 相关搜索:
- 合成有机化合物配体
- 抑制剂
- C36H33ClN2O7
- (2R,4R)-1-(5-氯-2-((3-氰基苄基)氧基)-4-((3-(2,3-二氢苯并[B] [1,4]二氧杂环己烯-6-基)-2-甲基苄基)氧基)苄基)-4-羟基吡咯烷-2-羧酸
- (4R)-1-[[5-氯-2-[(3-氰基苯基)甲氧基]-4-[[3-(2,3-二氢-1,4-苯并二氧杂环己烷-6-基)-2-甲基苯基]甲氧基]苯基]甲基]-4-羟基-D-脯氨酸
- 化合物BMS1166
- 1818314-88-3
- Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit
- BMS-1166
- (2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
- BMS 1166Q: What is
BMS 1166 Q: What is the CAS Number of
BMS 1166
- BMS-1166 (PD-1/PD-L1-IN1)
- PD-1/PD-L1-IN1 BMS-1166
- D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-
- BMS-1166 (Synonyms: PD-1/PD-L1-IN1)
- PD-1/PD-L1-IN1