CB-6644
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- CAS号:
- 2316817-88-4
- 英文名:
- CB-6644
- 英文别名:
- Chb-M';CB-6644;CB-6644
(CB6644;CB6644,CB-6644,Inhibitor,CB 6644,inhibit;Benzamide, 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-
- 中文名:
- CB-6644
- 中文别名:
- 化合物CB-6644
- CBNumber:
- CB24844617
- 分子式:
- C29H34ClFN4O5
- 分子量:
- 573.06
- MOL File:
- 2316817-88-4.mol
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CB-6644化学性质
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密度:
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1.34±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:100.0(Max Conc. mg/mL);174.5(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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13.13±0.20(Predicted)
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颜色:
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White to light yellow
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CB-6644性质、用途与生产工艺
CB-6644 一种选择性的 RUVBL1/2 复合体抑制剂。抑制 RUVBL1/2 的 ATP 酶活性，IC50 为 15 nM。具有抗癌活性。
CB-6644 (20 µM) interacts with the RUVBL1/2 complex in Ramos cells.
CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (including HCT116, NCI-1975, and HT29 cells) with an EC
50
range of 41 to 785 nM.
Cell Viability Assay
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Cell Line:
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123 cell lines such as HCT116, NCI-1975, and HT29 cells
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Concentration:
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0.001, 0.01, 0.1, 1, and 10 μM
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Incubation Time:
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72 hours
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Result:
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Potently killed cells with an EC
50
range of 41 to 785 nM.
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CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.
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Animal Model:
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SCID-beige mice bearing human tumor xenografts derived from either Burkitt’s lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines
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Dosage:
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150 mg/kg
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Administration:
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Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226
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Result:
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There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively.
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CB-6644
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-114429 | CB-6644
CB-6644 | 2316817-88-4 | 1mg | 2800元 |
| 2024/04/30 | HY-114429 | CB-6644
CB-6644 | 2316817-88-4 | 5mg | 6200元 |
2316817-88-4, CB-6644 相关搜索:
- 化合物CB-6644
- 2316817-88-4
- Benzamide, 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-
- CB6644,CB-6644,Inhibitor,CB 6644,inhibit
- Chb-M'
- CB-6644
(CB6644
- CB-6644