AZ32
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- CAS号:
- 2288709-96-4
- 英文名:
- AZ32
- 英文别名:
- AZ32;N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide;Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-;Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
- 中文名:
- AZ32
- 中文别名:
- 化合物AZ32;N-甲基-4-(6-苯基咪唑[1,2-A]吡嗪-3-)苯甲酰胺;N-甲基-4-(6-苯基咪唑并[1,2-A]吡嗪-3-基)苯甲酰胺
- CBNumber:
- CB28095233
- 分子式:
- C20H16N4O
- 分子量:
- 328.37
- MOL File:
- 2288709-96-4.mol
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AZ32化学性质
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 150 mg/ml
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形态:
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A solid
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酸度系数(pKa):
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14.63±0.46(Predicted)
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颜色:
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White to off-white
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AZ32性质、用途与生产工艺
AZ32 是一种口服可利用的,可穿透血脑屏障的 ATM 抑制剂,IC50<6.2 nM。在细胞中抑制 ATM,IC50 为 0.31 μM。
ATM
6.2 nM (IC
50
)
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ATM
0.31 μM (IC
50
, in cell)
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AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.
AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC
50
for approximately 22 hours.
AZ32
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-112305 | AZ32 | | 1 mg | 454元 |
2024/04/30 | HY-112305 | AZ32 AZ32 | | 5 mg | 1000元 |
2288709-96-4, AZ32 相关搜索:
- 药靶配体
- 标准品
- N-甲基-4-(6-苯基咪唑并[1,2-A]吡嗪-3-基)苯甲酰胺
- 化合物AZ32
- N-甲基-4-(6-苯基咪唑[1,2-A]吡嗪-3-)苯甲酰胺
- 2288709-96-4
- Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
- AZ32
- N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
- Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-