N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
|
|
- CAS号:
- 1420844-62-7
- 英文名:
- 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-
- 英文别名:
- Melanin probe-1;N-(2-(Diethylamino)ethyl)-5-fluoropicolinamide;N-[2-(diethylamino)ethyl]-5-fluoropyridine-2-carboxamide;2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-
- 中文名:
- N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
- 中文别名:
- N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
- CBNumber:
- CB28188205
- 分子式:
- C12H18FN3O
- 分子量:
- 239.29
- MOL File:
- 1420844-62-7.mol
|
|
|
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺化学性质
-
沸点:
-
370.3±37.0 °C(Predicted)
-
|
-
密度:
-
1.102±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 250 mg/mL (1044.76 mM)
-
|
-
酸度系数(pKa):
-
13.30±0.46(Predicted)
-
|
-
形态:
-
Oil
-
|
-
颜色:
-
Light yellow to yellow
-
|
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺性质、用途与生产工艺
Melanin probe-1 是一种基于 18 F-吡啶酰胺的 PET 探针。Melanin probe-1 可用于恶性黑色素瘤的 PET 显像。Melanin probe-1 具有较高的肿瘤靶向性、良好的肿瘤影像学对比,理想的生物分布模式和体内稳定性好。
Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency.
Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection.
Animal Model:
|
C57BL/6 mice bearing B16F10 murine melanomas
|
Dosage:
|
3.7 MBq (100 μCi)
|
Administration:
|
Tail vein
|
Result:
|
The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively.
|
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 Melanin probe-1 | 1420844-62-7 | 5mg | 1500元 |
2024/08/19 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 Melanin probe-1 | 1420844-62-7 | 10mM * 1mLin DMSO | 1650元 |
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
生产厂家
1420844-62-7, N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 相关搜索:
- N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
- 1420844-62-7
- N-[2-(diethylamino)ethyl]-5-fluoropyridine-2-carboxamide
- N-(2-(Diethylamino)ethyl)-5-fluoropicolinamide
- Melanin probe-1
- 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-