N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
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- CAS号:
- 1420844-62-7
- 英文名:
- 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-
- 英文别名:
- Melanin probe-1;N-(2-(Diethylamino)ethyl)-5-fluoropicolinamide;N-[2-(diethylamino)ethyl]-5-fluoropyridine-2-carboxamide;2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-
- 中文名:
- N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
- 中文别名:
- N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
- CBNumber:
- CB28188205
- 分子式:
- C12H18FN3O
- 分子量:
- 239.29
- MOL File:
- 1420844-62-7.mol
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N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺化学性质
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沸点:
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370.3±37.0 °C(Predicted)
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密度:
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1.102±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (1044.76 mM)
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酸度系数(pKa):
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13.30±0.46(Predicted)
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形态:
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Oil
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颜色:
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Light yellow to yellow
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N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺性质、用途与生产工艺
Melanin probe-1 是一种基于 18 F-吡啶酰胺的 PET 探针。Melanin probe-1 可用于恶性黑色素瘤的 PET 显像。Melanin probe-1 具有较高的肿瘤靶向性、良好的肿瘤影像学对比，理想的生物分布模式和体内稳定性好。
Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency.
Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection.
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Animal Model:
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C57BL/6 mice bearing B16F10 murine melanomas
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Dosage:
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3.7 MBq (100 μCi)
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Administration:
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Tail vein
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Result:
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The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively.
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N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
Melanin probe-1 | 1420844-62-7 | 5mg | 1500元 |
| 2024/08/19 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
Melanin probe-1 | 1420844-62-7 | 10mM * 1mLin DMSO | 1650元 |
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
生产厂家
1420844-62-7, N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 相关搜索:
- N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
- 1420844-62-7
- N-[2-(diethylamino)ethyl]-5-fluoropyridine-2-carboxamide
- N-(2-(Diethylamino)ethyl)-5-fluoropicolinamide
- Melanin probe-1
- 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-