PLURISIN #2
|
|
- CAS号:
- 56563-17-8
- 英文名:
- 1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl-
- 英文别名:
- PluriSIn #2;1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl-
- 中文名:
- PLURISIN #2
- 中文别名:
- CBNumber:
- CB28675514
- 分子式:
- C11H8FN3O3
- 分子量:
- 249.2
- MOL File:
- 56563-17-8.mol
|
|
|
PLURISIN #2化学性质
-
熔点:
-
223 °C
-
|
-
密度:
-
1.51±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
4°C, protect from light, stored under nitrogen
-
|
-
溶解度:
-
DMSO: 5 mg/mL (20.06 mM)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
6.88±0.10(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
PLURISIN #2性质、用途与生产工艺
PluriSIn #2 是一种拓扑异构酶 II α (TOP2A) 的选择性转录抑制剂。PluriSIn #2 是一种选择性消除未分化的人类多能干细胞 (hPSC) 的化合物。
PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level.
A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them.
Western Blot Analysis
Cell Line:
|
B153 and HUES9 human pluripotent stem cells (hPSCs)
|
Concentration:
|
20 µM
|
Incubation Time:
|
12 hours
|
Result:
|
Reduced TOP2A expression at the protein level.
|
PLURISIN #2
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-111630 | PluriSIn #2 | | 1 mg | 1136元 |
2024/04/30 | HY-111630 | PluriSIn #2 | 56563-17-8 | 5mg | 2500元 |
56563-17-8, PLURISIN #2 相关搜索:
- 56563-17-8
- PluriSIn #2
- 1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl-