普伐他汀类酯
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- CAS号:
- 85956-22-5
- 英文名:
- Pravastatin Lactone
- 英文别名:
- Pravastatin EP IMpurity D;R 414;SQ 31369;Pravastatin IMpurity D;PRAVASTATIN SODIUM(RG);Pravastatin class ester;Pravastatin Lactone_x000b_;Pravastatin Sodium EP Impurity D;(1S,3S,7S,8S,8aR)-3-Hydroxy-8-[2-[(;Pravastatin EP Impurity D (Pravastatin Lactone)
- 中文名:
- 普伐他汀类酯
- 中文别名:
- 普伐他汀类酯;普伐他汀杂质D;普伐他汀杂质04;普伐他汀EP杂质D;普伐他汀钠EP杂质D;普伐他汀杂质D (EP/BP);普伐他汀钠杂质Ⅲ(普伐他汀内酯);普伐他汀钠杂质D(EP) 标准品;普伐他汀EP杂质D(普伐他汀内酯);普伐他汀杂质4(普伐他汀EP杂质D)
- CBNumber:
- CB31176705
- 分子式:
- C23H34O6
- 分子量:
- 406.51
- MOL File:
- 85956-22-5.mol
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普伐他汀类酯化学性质
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熔点:
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140-143°C
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沸点:
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590.5±50.0 °C(Predicted)
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密度:
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1.18±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under Inert Atmosphere
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溶解度:
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DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 10 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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13.49±0.40(Predicted)
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稳定性:
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Hygroscopic
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CAS 数据库:
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85956-22-5
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普伐他汀类酯性质、用途与生产工艺
他汀类药物从最为其原型药物的氟伐他汀被发现到第一代洛伐他汀在美国由默克公司开发上市销售以来，其已经历了天然发酵他汀，人工合成他汀，第三代超级他汀三个阶段。随着对他汀类药物的作用机理和计算机辅助药物分子设计的不断深入研究和发展，认识到在现有他汀类药物或其类似物的适当位点引入氟原子对提高药物分子的HMGR酶抑制活性或降低药物的毒副作用有作用。普伐他汀类酯是普伐他汀杂质D。
普伐他汀类酯
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85956-22-5, 普伐他汀类酯 相关搜索:
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Various Metabolites and Impurities
- Heterocycles
- Chiral Reagents
- 杂质对照品
- 标准品
- 266-普伐他汀
- 普伐他汀杂质4(普伐他汀EP杂质D)
- 普伐他汀EP杂质D(普伐他汀内酯)
- 普伐他汀杂质04
- 普伐他汀钠EP杂质D
- 普伐他汀钠杂质D(EP) 标准品
- 普伐他汀杂质D (EP/BP)
- 普伐他汀钠杂质Ⅲ(普伐他汀内酯)
- 普伐他汀类酯
- 普伐他汀EP杂质D
- 普伐他汀杂质D
- 85956-22-5
- Pravastatin Sodium EP Impurity D
- Pravastatin EP IMpurity D
- Pravastatin Sodium Impurity Ⅲ:Pravastatin EP Impurity D (Pravastatin Lactone)
- Pravastatin LactoneQ: What is
Pravastatin Lactone Q: What is the CAS Number of
Pravastatin Lactone Q: What is the storage condition of
Pravastatin Lactone
- Pravastatin Lactone_x000b_
- Pravastatin EP Impurity D (Pravastatin Lactone)
- Butanoic acid, 2-methyl-, (1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
- (1S,3S,7S,8S,8aR)-3-Hydroxy-8-[2-[(
- Pravastatin Impurity 4（Pravastatin EP Impurity D）
- Pravastatin Sodium Impurity Ⅲ:Pravastatin EP Impurity D (Pravastatin Lactone)
- (1S,3S,7S,8S,8aR)-3-Hydroxy-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate
- [(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
- (1S,3S,7S,8S,8aR)-3-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
- Pravastatin class ester
- SQ 31369
- Pravastatin IMpurity D
- PRAVASTATIN SODIUM(RG)
- (1S)-1β-[2-[[(2R,4R)-3,4,5,6-Tetrahydro-4β-hydroxy-6-oxo-2H-pyran]-2-yl]ethyl]-1,2,6,7,8,8aβ-hexahydro-2β-methyl-8α-[[(S)-2-methyl-1-oxobutyl]oxy]naphthalen-6β-ol
- R 414
- (2S)-2-Methyl-Butanoic Acid (1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester