Tritoqualine
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- CAS号:
- 14504-73-5
- 英文名:
- Tritoqualine
- 英文别名:
- Tritocalin;Hypostamine;Inhibostamin;7-Amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 7-amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-
- 中文名:
- Tritoqualine
- 中文别名:
- 酞茂异喹;化合物 T17166
- CBNumber:
- CB31180009
- 分子式:
- C26H32N2O8
- 分子量:
- 500.54
- MOL File:
- 14504-73-5.mol
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Tritoqualine化学性质
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熔点:
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183°
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沸点:
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647.2±55.0 °C(Predicted)
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密度:
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1.296±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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6.22±0.40(Predicted)
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Tritoqualine性质、用途与生产工艺
Tritoqualine 是一种组氨酸脱羧酶抑制剂。
The effect of Tritoqualine (TRQ) on the CCl
4
-induced enzyme leakage is investigated by pretreatment of rats with Tritoqualine (200 mg/kg/day, p.o., 7 days). The ratio of lactate dehydrogenase (LDH) release from the cells of Tritoqualine-pretreated rats is significantly less than that in control rats. The rate of malondialdehyde (MDA) production is accelerated after the addition of 7.8 mM CCl
4
. Tritoqualine reduces its rate in a dose dependent manner, and it completely prevents CCl
4
-stimulated lipid peroxidation at a concentration of 33 μM.
A single administration of CCl
4
(0.75 mL/kg, p.o.) causes a five-fold increase of in vivo lipid peroxidation in the liver. In contrast, a reduction of 37% in the lipid peroxidation is obtained by Tritoqualine (100 mg/kg) pretreatment for 14 days prior to CCl
4
treatment. A 63% reduction is observed in vitamin E (25 mg/kg) pretreated rats.
Tritoqualine
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上游原料
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14504-73-5, Tritoqualine 相关搜索:
- 抑制剂
- C26H32N2O8
- 化合物 T17166
- 酞茂异喹
- 14504-73-5
- 1(3H)-Isobenzofuranone, 7-amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-
- Tritocalin
- Inhibostamin
- Hypostamine
- 7-Amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one