4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

生物活性靶点体内研究

CAS号:: 114568-26-2

英文名:: 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

英文别名:: Patomostat;4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate;4-Guanidinobenzoic acid 4-[[2-(2,5-dioxopyrrolidin-1-yl)ethyl]thio]phenyl ester;Benzoic acid, 4-[(aminoiminomethyl)amino]-, 4-[[2-(2,5-dioxo-1-pyrrolidinyl)ethyl]thio]phenyl ester

中文名:: 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

中文别名:: 化合物 PATAMOSTAT

CBNumber:: CB31373166

分子式:: C20H20N4O4S

分子量:: 412.46

MOL File:: 114568-26-2.mol

化学性质安全信息用途供应商 6

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate化学性质

熔点:: 201.6 °C

沸点:: 653.2±65.0 °C(Predicted)

密度:: 1.41±0.1 g/cm3(Predicted)

储存条件:: 4°C, away from moisture and light

酸度系数(pKa):: 10.17±0.10(Predicted)

安全信息

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate性质、用途与生产工艺

生物活性

Patamostat (E-3123) 是一种有效的蛋白酶 (protease) 抑制剂。Patamostat 有效抑制胰蛋白酶，纤溶酶和凝血酶，IC50 分别为 39 nM，950 nM 和 1.9 μM。Patamostat 有潜力用于急性胰腺炎的研究。

靶点

IC50: 39 nM (trypsin), 950 nM (plasmin) and 1.9 μM (thrombin)

Intravenous infusion of Patamostat (E-3123) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduced mortality after the induction of pancreatitis in a dose-dependent manner. In dogs with pancreatitis, increases in serum trypsin and lipase activities were significantly reduced by infusion of Patamostat at 1.0 and 3.0 mg/kg.
Patamostat (E3123; continuous infusion in a dose of 2 mg/kg per h) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats.

Animal Model:	Male Wistar rats weighing about 350 g
Dosage:	2 mg/kg
Administration:	Continuous infusion per h for 1 h
Result:	Significantly improved the survival rate.

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate 上下游产品信息

上游原料

下游产品

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate 生产厂家

全球有 6家供应商 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
常州博嘉生物医药科技有限公司	2122619822	czbjpharma@126.com	中国	18488	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
上海陌孚医药科技有限公司	021-59167510 18117107507	vip@med-life.cn	中国	5019	58
銳迪國際科技有限公司	18024082417	market@ubiochem.com	中国	9154	58

114568-26-2, 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate 相关搜索:

化合物 PATAMOSTAT
114568-26-2
Benzoic acid, 4-[(aminoiminomethyl)amino]-, 4-[[2-(2,5-dioxo-1-pyrrolidinyl)ethyl]thio]phenyl ester
Patomostat
4-Guanidinobenzoic acid 4-[[2-(2,5-dioxopyrrolidin-1-yl)ethyl]thio]phenyl ester
4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate