(S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯
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- CAS号:
- 202825-45-4
- 英文名:
- RalfinaMide Mesylate
- 英文别名:
- CS-1138;RALFINAMIDE MESYLATE;FCE-26742A (mesylate);(S)-2-((4-((2-fluorobenzyl)oxy)benzyl)aMino)propanaMide Methanesulfonate;(S)-2-((4-((2-fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonic acid;(2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate;FCE-26742A,Na channels,Na+ channels,Ralfinamide mesylate,Sodium Channel,Ralfinamide,inhibit,Inhibitor
- 中文名:
- (S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯
- 中文别名:
- 邻氟沙芬酰胺甲磺酸盐;化合物RALFINAMIDE MESYLATE;RALFINAMIDE MESYLATE,NA +通道阻滞剂;(S)-2-((4-((2-氟苄基)氧基)苄基)氨基)丙酰胺甲磺酸盐;S)-2-((4-((2-氟苄基)氧基)苄基)-氨)丙酰胺 甲烷磺酸酯;(S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯
- CBNumber:
- CB32538283
- 分子式:
- C18H23FN2O5S
- 分子量:
- 398.4490232
- MOL File:
- 202825-45-4.mol
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(S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯化学性质
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熔点:
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230-235°C
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储存条件:
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2-8°C
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溶解度:
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H2O: >15mg/mL
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形态:
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powder
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颜色:
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white to beige
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旋光性 (optical activity):
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[α]/D 10 to 15° (c=1 HOAc)
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(S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯性质、用途与生产工艺
Ralfinamide mesylate (FCE-26742A mesylate) 是一种口服可利用，来源于 α-aminoamide 的钠离子通道阻滞剂, 具有镇痛作用。
Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain.
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Animal Model:
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81 adult male Sprague–Dawley male rats (260–460 g)
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Dosage:
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80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)
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Administration:
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Oral gavage; twice daily; until postoperative day 42
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Result:
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Suppressed neuropathic pain.
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(S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯
上下游产品信息
上游原料
下游产品
(S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯
生产厂家
202825-45-4, (S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯 相关搜索:
- 抑制剂
- 生化试剂
- 合成
- C17H19FN2O2CH3SO3H
- RALFINAMIDE MESYLATE,NA +通道阻滞剂
- S)-2-((4-((2-氟苄基)氧基)苄基)-氨)丙酰胺 甲烷磺酸酯
- 邻氟沙芬酰胺甲磺酸盐
- 化合物RALFINAMIDE MESYLATE
- (S)-2-((4-((2-氟苄基)氧基)苄基)氨基)丙酰胺甲磺酸盐
- (S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯
- 202825-45-4
- FCE-26742A,Na channels,Na+ channels,Ralfinamide mesylate,Sodium Channel,Ralfinamide,inhibit,Inhibitor
- (S)-2-((4-((2-fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonic acid
- CS-1138
- FCE-26742A (mesylate)
- (2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate
- (S)-2-((4-((2-fluorobenzyl)oxy)benzyl)aMino)propanaMide Methanesulfonate
- RALFINAMIDE MESYLATE