化合物AMN 082 DIHYDROCHLORIDE
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- CAS号:
- 97075-46-2
- 英文名:
- 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
- 英文别名:
- N,N'-dibenzhydrylethane-1,2-diamine;N1,N2-Dibenzhydrylethane-1,2-diamine dihydrochloride;1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride;1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
- 中文名:
- 化合物AMN 082 DIHYDROCHLORIDE
- 中文别名:
- N1,N2-二苯甲基乙烷-1,2-二胺二盐酸盐;化合物AMN 082 DIHYDROCHLORIDE
- CBNumber:
- CB32609376
- 分子式:
- C28H29ClN2
- 分子量:
- 429
- MOL File:
- 97075-46-2.mol
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化合物AMN 082 DIHYDROCHLORIDE化学性质
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储存条件:
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-20°C
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溶解度:
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<46.55mg/ml in DMSO;insoluble in H2O
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形态:
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solid
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颜色:
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White
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化合物AMN 082 DIHYDROCHLORIDE性质、用途与生产工艺
AMN082 是一种选择性，具有口服活性，可透过血脑屏障的 mGluR7 激动剂，通过跨膜区的变构位点直接激活受体信号。在表达 mGluR7 的转染哺乳动物细胞上，AMN082 有效抑制 cAMP 积累并刺激 GTPγS 结合 (EC50, 64-290 nM)。AMN082 对其他 mGluR 亚型和选择性离子型谷氨酸受体具有选择性。具有抗抑郁作用。
Preincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate.
AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7
+/+
mice (C57BL/6 genetic background).
AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine or Morphine injection during repeated drug administration or before Cocaine or Morphine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine or Morphine locomotor sensitization.
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Animal Model:
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Male Swiss mice (20-25g)
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Dosage:
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1.25, 2.5, 5.0 mg/kg
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Administration:
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I.p.; given 30 min prior to Cocaine (10 mg/kg) or Morphine (10 mg/kg) challenge on day 17 or 20, respectively
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Result:
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Significantly attenuated the expression of Cocaine-induced locomotor sensitization; Attenuated the induction of Morphine-induced sensitization.
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化合物AMN 082 DIHYDROCHLORIDE
上下游产品信息
上游原料
下游产品
化合物AMN 082 DIHYDROCHLORIDE
生产厂家
97075-46-2, 化合物AMN 082 DIHYDROCHLORIDE 相关搜索:
- 合成有机化合物配体
- C28H30Cl2N2
- N1,N2-二苯甲基乙烷-1,2-二胺二盐酸盐
- 化合物AMN 082 DIHYDROCHLORIDE
- 97075-46-2
- 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
- N1,N2-Dibenzhydrylethane-1,2-diamine dihydrochloride
- N,N'-dibenzhydrylethane-1,2-diamine
- 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride