网站主页 >> CAS数据库列表 >> 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
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- CAS号:
- 858474-14-3
- 英文名:
- 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- 英文别名:
- NSC23925;NSC-23925;NSC23925 HCl;NSC23925,NSC-23925;2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;2-(4-Methoxyphenyl)-a-2-piperidinyl-4-quinolinemethanol Dihydrochloride;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride;(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride
- 中文名:
- 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
- 中文别名:
- 化合物 T16352;2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
- CBNumber:
- CB32652756
- 分子式:
- C22H25ClN2O2
- 分子量:
- 384.9
- MOL File:
- 858474-14-3.mol
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2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE化学性质
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储存条件:
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room temp
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溶解度:
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H2O: soluble5mg/mL (clear solution)
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形态:
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powder
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颜色:
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white to beige
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2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE性质、用途与生产工艺
NSC23925 是一种新型的,有选择性且有效的 P-糖蛋白 (Pgp) 抑制剂。
NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor. SKOV-3 cells with long-term exposure of 1 μM NSC23925 show stable growth in culture medium. NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 µM. The IC
50
for NSC23925 is 8 µM in SKOV-3/SKOV-3
TR
and 25 µM in OVCAR8/OVCAR8
TR
cell lines, whereas the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3
TR
or OVCAR8
TR
to cytotoxic drugs is 0.5 µM to 1 µM.
Both saline alone and NSC23925 alone treated tumors grow progressively. The usage of NSC23925 in paclitaxel chemotherapy significantly prolongs anticancer efficacy of paclitaxel.
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-19626 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE NSC23925 | 858474-14-3 | 5mg | 1100元 |
2024/08/19 | HY-19626 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE NSC23925 | 858474-14-3 | 10mM * 1mLin DMSO | 1210元 |
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
生产厂家
858474-14-3, 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE 相关搜索:
- 化合物 T16352
- 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
- 858474-14-3
- 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- NSC23925,NSC-23925
- 2-(4-Methoxyphenyl)-a-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- NSC23925 HCl
- (2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride
- 4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride
- NSC-23925
- NSC23925
- [2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
- 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE