DEBIO 0932
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- CAS号:
- 1061318-81-7
- 英文名:
- Debio 0932 ,CUDC-305
- 英文别名:
- CS-1423;bio 0932;CUDC-305;Debio 0932;Debio 0932 ,CUDC-305;CUDC-305 (DEBIO-0932 );1H-Imidazo[4,5-c]pyridine-1-ethanamine, 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-
- 中文名:
- DEBIO 0932
- 中文别名:
- 德比奥 0932;BIO 0932;化合物 T15088;HSP90抑制剂(DEBIO 0932);2-((6-(二甲基氨基)苯并[D][1,3]二氧戊环-5-基)硫)-1-(2-(新戊基氨基)乙基)-1H-咪唑并[4,5-C]吡啶-4-胺
- CBNumber:
- CB32667714
- 分子式:
- C22H30N6O2S
- 分子量:
- 442.58
- MOL File:
- 1061318-81-7.mol
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DEBIO 0932化学性质
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沸点:
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654.8±65.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:33.0(Max Conc. mg/mL);74.56(Max Conc. mM)
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形态:
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A crystalline solid
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酸度系数(pKa):
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10.02±0.19(Predicted)
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颜色:
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White to yellow
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DEBIO 0932性质、用途与生产工艺
用途
一种HSP90(热休克蛋白90)抑制剂，对 HSP90α和 HSP90β的IC50值分别为100和103nM。Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance.
DEBIO 0932
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-13469 | DEBIO 0932
Debio 0932 | 1061318-81-7 | 2mg | 950元 |
| 2024/08/19 | HY-13469 | DEBIO 0932
Debio 0932 | 1061318-81-7 | 10mM * 1mLin DMSO | 1363元 |
1061318-81-7, DEBIO 0932 相关搜索:
- 抑制剂
- 细胞生物学试剂
- 2-((6-(二甲基氨基)苯并[D][1,3]二氧戊环-5-基)硫)-1-(2-(新戊基氨基)乙基)-1H-咪唑并[4,5-C]吡啶-4-胺
- BIO 0932
- 化合物 T15088
- 德比奥 0932
- HSP90抑制剂(DEBIO 0932)
- 1061318-81-7
- bio 0932
- CS-1423
- 1H-Imidazo[4,5-c]pyridine-1-ethanamine, 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-
- CUDC-305
- CUDC-305 (DEBIO-0932 )
- Debio 0932 ,CUDC-305
- Debio 0932