BPR1J-097
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- CAS号:
- 1327167-19-0
- 英文名:
- BPR1J-097
- 英文别名:
- CS-2096;CS-2356;BPR1J-097;BPR1J-097 hydrochloride;BPR1J-097;BPR1J 097;BPR1J097;N-[5-(3-Benzenesulfonamidophenyl)-1H-pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide;4-(4-methylpiperazin-1-yl)-N-(5-(3-(phenylsulfonamido)phenyl)-1H-pyrazol-3-yl)benzamide;N-(3-(3-[(phenylsulfonyl)amino]phenyl)-1H-pyrazol-5-yl)-4-(4-methylpiperazino) benzamide;Benzamide, 4-(4-methyl-1-piperazinyl)-N-[5-[3-[(phenylsulfonyl)amino]phenyl]-1H-pyrazol-3-yl]-;BPR1J 097,CD135,Fms like tyrosine kinase 3,BPR-1J-097,FLT3,Cluster of differentiation antigen 135,inhibit,Inhibitor,BPR1J-097
- 中文名:
- BPR1J-097
- 中文别名:
- 化合物BPR1J-097;PERFEMIKER]BPR1J-097,98%;4-(4-甲基哌嗪-1-基)-N-(5-(3-(苯磺酰胺基)苯基)-1H-吡唑-3-基)苯甲酰胺
- CBNumber:
- CB32667855
- 分子式:
- C27H28N6O3S
- 分子量:
- 516.61
- MOL File:
- 1327167-19-0.mol
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BPR1J-097化学性质
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熔点:
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247-248 °C
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密度:
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1.368±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:10.0(Max Conc. mg/mL);19.36(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.07(Max Conc. mM)
DMF:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.27(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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8.17±0.10(Predicted)
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颜色:
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White to off-white
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BPR1J-097性质、用途与生产工艺
BPR1J-097 Hydrochloride 是一个新型且强效的 FLT3 抑制剂，其 IC50 值为 11 nM。
BPR1J-097 Hydrochloride is a novel and potent FLT3 inhibitor with an IC
50
of 11nM. Phosphorylation of all FLT3-WT, FLT3-IDT, and FLT3-D835Y are inhibited by BPR1J-097 Hydrochloride at a concentration as low as 10 nM. BPR1J-097 Hydrochloride suppresses the phosphorylation of FLT3 and STAT5 in a dose-dependent manner. The IC
50
values of BPR1J-097 Hydrochloride on MOLM-13 and MV4-11 cells are 21±7 and 46±14 nM, respectively. The emergence of active caspase-3 is observed in MOLM-13 cells treated with BPR1J-097 Hydrochloride at 10 nM. The effect of BPR1J-097 Hydrochloride seems to be weaker in MV4-11 cells as caspase-3 is not evident until 100 nM of BPR1J-097 Hydrochloride is applied to treat cells.
After i.v. administration of mice with BPR1J-097 Hydrochloride at two cycles of 10 or 25 mg/kg, a clear dose-dependent anti-tumour effect is observed. Tumours in mice treated with BPR1J-097 Hydrochloride (25 mg/kg per day) stop growing. BPR1J-097 Hydrochloride (25 mg/kg) shows a significant tumour shrinkage effect on the subcutaneously growing MOLM-13 tumours in a size of >2000 mm
3
. BPR1J-097 Hydrochloride (10 and 25 mg/kg) also produces a dose-dependent growth reduction and shrinkage of another model using MV4-11 cells. It is noted that a prolonged disappearance of MV4-11 tumours is observed in mice treated with BPR1J-097 Hydrochloride at 25 mg/kg. There is little (3%) or no body weight loss of BPR1J-097 Hydrochloride-treated nude mice during the observation periods in these
in vivo
studies.
BPR1J-097
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-13537A | BPR1J-097
BPR1J-097 Hydrochloride | 1327167-19-0 | 2mg | 500元 |
| 2024/08/19 | HY-13537A | BPR1J-097
BPR1J-097 Hydrochloride | 1327167-19-0 | 5mg | 700元 |
1327167-19-0, BPR1J-097 相关搜索:
- Inhibitors
- 标准品
- 抑制剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- CHClNOS
- PERFEMIKER]BPR1J-097,98%
- 4-(4-甲基哌嗪-1-基)-N-(5-(3-(苯磺酰胺基)苯基)-1H-吡唑-3-基)苯甲酰胺
- 化合物BPR1J-097
- 1327167-19-0
- BPR1J 097,CD135,Fms like tyrosine kinase 3,BPR-1J-097,FLT3,Cluster of differentiation antigen 135,inhibit,Inhibitor,BPR1J-097
- BPR1J-097;BPR1J 097;BPR1J097
- CS-2096
- CS-2356
- BPR1J-097 hydrochloride
- Benzamide, 4-(4-methyl-1-piperazinyl)-N-[5-[3-[(phenylsulfonyl)amino]phenyl]-1H-pyrazol-3-yl]-
- N-[5-(3-Benzenesulfonamidophenyl)-1H-pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
- N-(3-(3-[(phenylsulfonyl)amino]phenyl)-1H-pyrazol-5-yl)-4-(4-methylpiperazino) benzamide
- 4-(4-methylpiperazin-1-yl)-N-(5-(3-(phenylsulfonamido)phenyl)-1H-pyrazol-3-yl)benzamide
- BPR1J-097