904763-27-5
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- CAS号:
- 904763-27-5
- 英文名:
- ATN 161 TFA salt
- 英文别名:
- ATN-161 TFA;ATN161 TFA salt;ATN-161 TFA salt;ATN 161 TFA salt;ATN-161 Trifluoroacetate;ATN-161 trifluoroacetate salt;ATN 161 trifluoroacetate salt,ATN161 trifluoroacetate salt,ATN161,inhibit,ATN-161,ATN 161,Integrin,Inhibitor
- 中文名:
- 904763-27-5
- 中文别名:
- 化合物ATN-161 TRIFLUOROACETATE SALT
- CBNumber:
- CB32729351
- 分子式:
- C25H36F3N9O10S
- 分子量:
- 711.6678496
- MOL File:
- 904763-27-5.mol
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904763-27-5化学性质
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熔点:
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>229°C (dec.)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Water (Slightly, Heated, Sonicated)
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形态:
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Solid
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颜色:
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White to Off-White
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904763-27-5性质、用途与生产工艺
ATN-161 trifluoroacetate salt 是一种新型 integrin α5β1 拮抗剂,在肝转移模型小鼠模型中,抑制血管生成。
The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03). ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group).
The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564.
904763-27-5
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13535A | 904763-27-5 ATN-161 trifluoroacetate salt | 904763-27-5 | 2 mg | 800元 |
2024/08/19 | HY-13535A | 904763-27-5 ATN-161 trifluoroacetate salt | 904763-27-5 | 5mg | 1100元 |
904763-27-5, 904763-27-5 相关搜索:
- 化合物ATN-161 TRIFLUOROACETATE SALT
- 904763-27-5
- ATN 161 trifluoroacetate salt,ATN161 trifluoroacetate salt,ATN161,inhibit,ATN-161,ATN 161,Integrin,Inhibitor
- ATN-161 Trifluoroacetate
- ATN-161 TFA
- ATN 161 TFA salt
- ATN-161 trifluoroacetate salt
- ATN-161 TFA salt
- ATN161 TFA salt