SCR7

SCR7性质、用途与生产工艺

生物活性

SCR7 是一种特异性 DNA Ligase IV 抑制剂，其阻断非同源性末端连接(NHEJ)。

体外研究

SCR7 effectively inhibits the formation of multimers at 200 μM and above. SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. SCR7 suppresses the NHEJ repair of CRISPR-Cas9-induced DSBs.

体内研究

SCR7 treatment (10 mg/kg, i.m.) significantly reduces breast adenocarcinoma-induced tumor, and exhibits 4-fold increase in lifespan compared with control group. However, in Swiss albino mice with Dalton’s lymphoma tumor model, SCR7 (20 mg/kg, i.p.) exhibits neither tumor regression nor increase in lifespan. In BALB/c mice, SCR7 (20 mg/kg, i.p.) significantly enhances the cytotoxic effects of radiation, etoposide and 3-Aminobenzamide on tumor derived from Dalton’s lymphoma (DLA) cells.

SCR7 上下游产品信息

上游原料

下游产品

SCR7 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/01/25	HY-12742	SCR7 SCR7	1533426-72-0	5mg	2800元

SCR7 生产厂家

 

1533426-72-0, SCR7 相关搜索:

• Inhibitors
• 标准品
• 小分子抑制剂
• 抑制剂
• 小分子抑制剂，天然产物
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• 1533426-72-0
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• CS-1733
• 4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-
• SCR7 USP/EP/BP
• SCR7
• 5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• 5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol
• 2,3-Dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone