PF-CBP1
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- CAS号:
- 2070014-93-4
- 英文名:
- PF-CBP1 (hydrochloride)
- 英文别名:
- PF-CBP1 (hydrochloride);PF-CBP1 hydrochloride(b);HFOZCHHWLMTUTP-UHFFFAOYSA-N;4-[2-[5-(3,5-dimethylisoxazol-4-yl)-2-[2-(4-propoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholine;5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole;4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride;5-?(3,?5-Dimethyl-?4-?isoxazolyl)?-?1-?[2-?(4-?morpholinyl)?ethyl]?-?2-?[2-?(4-?propoxyphenyl)?ethyl]?-1H-?benzimidazole Hydrochloride;parkinson's disease,HATs,cortical,inflammatory,HAT,Histone Acetyltransferase,PF CBP1 hydrochloride,inhibit,RGS4,epilepsy,Epigenetic Reader Domain,PF-CBP1,PFCBP1 hydrochloride,Inhibitor,neurological disorder,PF-CBP-1 hydrochloride,neuron
- 中文名:
- PF-CBP1
- 中文别名:
- PF-CBP1盐酸;化合物PF-CBP1 HYDROCHLORIDE;4-(2-(5-(3,5-二甲基异恶唑-4-基)-2-(4-丙氧基苯乙基)-1H-苯并[D]咪唑-1-基)乙基)吗啉盐酸盐
- CBNumber:
- CB33122348
- 分子式:
- C29H37ClN4O3
- 分子量:
- 525.09
- MOL File:
- 2070014-93-4.mol
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PF-CBP1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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≥52.5 mg/mL in DMSO; insoluble in H2O; ≥40.6 mg/mL in EtOH
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形态:
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solid
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颜色:
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White to yellow
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PF-CBP1性质、用途与生产工艺
PF-CBP1 hydrochloride 是 CREB 结合蛋白溴结构域 (CBP BRD) 的高选择性抑制剂。PF-CBP1 抑制 CREBBP 和 EP300 溴结构域的 IC50 分别为 125 nM 和 363 nM。PF-CBP1 hydrochloride 降低 LPS 诱导的巨噬细胞中炎症因子 (IL-1β、IL-6 和IFN-β) 的表达。PF-CBP1 hydrochloride 也可下调皮质神经元 RGS4 的表达,可用于癫痫和帕金森病等多种神经疾病的研究。
CREBBP
125 nM (IC
50
)
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EP300
363 nM (IC
50
)
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CBP
0.19 μM (Kd)
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BRD4
20 μM (Kd)
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ITC is the label-free technique for determining K
D
values, PF-CBP1 is against CBP (K
d
=0.19 μM) and >105-fold selective over BRD4 (K
d
>20 μM) by ITC.PF-CBP1 displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins, it against BRD2-1,BRD3-1, BRD3-2,BRD4-1, BRD4-2, BRDT-1, TAF1-2, and TAF1L-2 with IC
50
values of 1.24 μM, 1.38 μM, 4.22 μM, 1.54 μM, 9.75 μM, 2.44 μM, 3.39 μM and 7.29 μM, respectively.PF-CBP1 (3-10 μM; pretreatment 30 mins; 4 hours) moderately reduces LPS-induced IL-6 and IFN-b expression in the J774 cell at 10 μM. And it decreases IL-1b expression evidently at 3 μM.PF-CBP1 (100 nM-1000 nM;24 hours) significantly reduced RGS4 mRNA levels(49% reduction) relative to vehicle in cortical neuron cells.
PF-CBP1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-19999A | PF-CBP1 PF-CBP1 hydrochloride | 2070014-93-4 | 5mg | 500元 |
2024/08/19 | HY-19999A | PF-CBP1 PF-CBP1 hydrochloride | 2070014-93-4 | 10mg | 750元 |
2070014-93-4, PF-CBP1 相关搜索:
- 药靶配体
- C29H37ClN4O3
- 4-(2-(5-(3,5-二甲基异恶唑-4-基)-2-(4-丙氧基苯乙基)-1H-苯并[D]咪唑-1-基)乙基)吗啉盐酸盐
- PF-CBP1盐酸
- 化合物PF-CBP1 HYDROCHLORIDE
- 2070014-93-4
- 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride
- PF-CBP1 hydrochloride(b)
- parkinson's disease,HATs,cortical,inflammatory,HAT,Histone Acetyltransferase,PF CBP1 hydrochloride,inhibit,RGS4,epilepsy,Epigenetic Reader Domain,PF-CBP1,PFCBP1 hydrochloride,Inhibitor,neurological disorder,PF-CBP-1 hydrochloride,neuron
- HFOZCHHWLMTUTP-UHFFFAOYSA-N
- 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole
- 5-?(3,?5-Dimethyl-?4-?isoxazolyl)?-?1-?[2-?(4-?morpholinyl)?ethyl]?-?2-?[2-?(4-?propoxyphenyl)?ethyl]?-1H-?benzimidazole Hydrochloride
- 4-[2-[5-(3,5-dimethylisoxazol-4-yl)-2-[2-(4-propoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholine
- PF-CBP1 (hydrochloride)