FMK-9A; FMK9A
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- CAS号:
- 1955550-51-2
- 英文名:
- FMK 9a
- 英文别名:
- FMK 9a;FMK-9A; FMK9A;inhibit,FMK 9a,Autophagy,Inhibitor;1-Naphthalenecarboxamide, N-[(1S)-2-[(3-fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-
- 中文名:
- FMK-9A; FMK9A
- 中文别名:
- 化合物FMK 9A;化合物 T15303;AUTOPHAGIN-1抑制剂(FMK 9A)
- CBNumber:
- CB33171694
- 分子式:
- C23H21FN2O3
- 分子量:
- 392.42
- MOL File:
- 1955550-51-2.mol
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FMK-9A; FMK9A化学性质
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沸点:
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724.6±60.0 °C(Predicted)
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密度:
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1.241±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO: 100 mg/mL (254.83 mM)
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酸度系数(pKa):
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12.82±0.46(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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FMK-9A; FMK9A性质、用途与生产工艺
FMK 9a是autophagin-1的抑制剂，在FRET和LRA试验中测定的IC50值分别为80 和73 nM。
IC50: 80 nM (autophagin-1, FRET assay); 73 nM (autophagin-1, LRA assay)
ATG4B or autophagin-1 is a cysteine protease that cleaves ATG8 family proteins. ATG4B plays essential roles in the autophagosome formation and the autophagy pathway. FMK 9a shows strong inhibition of ATG4B, with IC
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values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays, respectively. LC−MS/MS study indicates that FMK 9a forms an irreversible covalent bond with the more reactive thiol group of Cys74 located at the catalytic site of ATG4B and thus inactivates ATG4B proteolytic activity.
FMK 9a shows moderate solubility (LYSA: 41 μg/mL) and high human and mouse liver microsome clearances of 13.9 and 70 mL/kg per minute.
FMK-9A; FMK9A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100522 | FMK-9A; FMK9A
FMK 9a | 1955550-51-2 | 5mg | 3500元 |
| 2024/04/30 | HY-100522 | FMK-9A; FMK9A
FMK 9a | 1955550-51-2 | 10mM * 1mLin DMSO | 3850元 |
1955550-51-2, FMK-9A; FMK9A 相关搜索:
- 定做
- 细胞生物学试剂
- 化合物FMK 9A
- 化合物 T15303
- AUTOPHAGIN-1抑制剂(FMK 9A)
- 1955550-51-2
- inhibit,FMK 9a,Autophagy,Inhibitor
- FMK-9A; FMK9A
- 1-Naphthalenecarboxamide, N-[(1S)-2-[(3-fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-
- FMK 9a