489416-12-8
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- CAS号:
- 489416-12-8
- 英文名:
- ST-193
- 英文别名:
- ST-193;ST-193 hydrochlorid;ST193 HYDROCHLORIDE; ST 193 HYDROCHLORIDE;ST-193,inhibit,Inhibitor,Arenavirus,ST193,ST 193;1H-Benzimidazol-5-amine, 1-(4-methoxyphenyl)-N-[[4-(1-methylethyl)phenyl]methyl]-
- 中文名:
- 489416-12-8
- 中文别名:
- 化合物ST-193
- CBNumber:
- CB33171700
- 分子式:
- C24H25N3O
- 分子量:
- 371.47
- MOL File:
- 489416-12-8.mol
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489416-12-8化学性质
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沸点:
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562.5±60.0 °C(Predicted)
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密度:
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1.12±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥ 150 mg/mL (403.80 mM)
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酸度系数(pKa):
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5.20±0.10(Predicted)
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形态:
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Solid
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颜色:
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Off-white to pink
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489416-12-8性质、用途与生产工艺
ST-193是有效广谱的arenavirus抑制剂;抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。
IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)
ST-193 inhibits LASV pseudotypes with an IC
50
of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC
50
s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM.
ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups.
489416-12-8
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101441 | ST-193 | | 1 mg | 1160元 |
2024/08/19 | HY-101441 | 489416-12-8 ST-193 | 489416-12-8 | 5mg | 2400元 |
489416-12-8, 489416-12-8 相关搜索:
- 化合物ST-193
- 489416-12-8
- ST-193,inhibit,Inhibitor,Arenavirus,ST193,ST 193
- ST-193 hydrochlorid
- ST193 HYDROCHLORIDE; ST 193 HYDROCHLORIDE
- 1H-Benzimidazol-5-amine, 1-(4-methoxyphenyl)-N-[[4-(1-methylethyl)phenyl]methyl]-
- ST-193