413599-62-9
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- CAS号:
- 413599-62-9
- 英文名:
- ZD-4190
- 英文别名:
- ZD-4190;ZD-4190;ZD 4190;ZD4190;7-(2-(1H-1,2,3-Triazol-1-yl)ethoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine;4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]-;Inhibitor,inhibit,Vascular endothelial growth factor receptor,VEGFR,Epidermal growth factor receptor,EGFR,ZD 4190,ErbB-1,HER1,ZD-4190,ZD4190
- 中文名:
- 413599-62-9
- 中文别名:
- 化合物ZD-4190;7-(2-(1H-1,2,3-三唑-1-基)乙氧基)-N-(4--溴-2-氟苯基)-6-甲氧基嘧啶-4-胺
- CBNumber:
- CB33175607
- 分子式:
- C19H16BrFN6O2
- 分子量:
- 459.27
- MOL File:
- 413599-62-9.mol
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413599-62-9化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 20.83 mg/mL (45.35 mM);Water : < 0.1 mg/mL (insoluble)
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形态:
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Solid
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颜色:
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White to off-white
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413599-62-9性质、用途与生产工艺
ZD-4190是VEGF RTK抑制剂，对KDR和Flt-1的IC50值分别为29 ± 4 nM和708 ± 63 nM。
| Target | Value |
KDR
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Flt-1
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ZD4190 exhibits cytotoxic activity against the tumor cells.
ZD4190 (100 mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, 18F-FPPRGD2 uptake has decreased significantly relative to baseline by 26.74±8.12% (p<0.05) on day 1 and by 41.19±6.63% (p<0.01) on day 3, then has returned to baseline on day 7. Tumor uptake of 18F-FLT has also decreased on both day 1 and day 3 after initiation of ZD4190 treatment. However, ZD4190 does not significantly change 18F-FDG uptake in tumors, compared with the control group. ZD4190 (50 mg/kg, p.o.) prevents outgrowth of residual tumour in a muscle model of minimal residual carcinoma. ZD4190 (12.5-100 mg/kg, p.o.) produces a dose-dependent reduction in K(trans) in PC-3 prostate tumors. At 100 mg/kg, ZD4190 reduces K(trans) in PC-3 tumors by 31% following 2 doses and by 53% following 8 doses.
413599-62-9
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-U00002 | ZD-4190 | | 1 mg | 850元 |
| 2024/08/19 | HY-U00002 | 413599-62-9
ZD-4190 | 413599-62-9 | 5mg | 2200元 |
413599-62-9, 413599-62-9 相关搜索:
- 抑制剂
- 药靶配体
- C19H16BrFN6O2
- 7-(2-(1H-1,2,3-三唑-1-基)乙氧基)-N-(4--溴-2-氟苯基)-6-甲氧基嘧啶-4-胺
- 化合物ZD-4190
- 413599-62-9
- 7-(2-(1H-1,2,3-Triazol-1-yl)ethoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
- Inhibitor,inhibit,Vascular endothelial growth factor receptor,VEGFR,Epidermal growth factor receptor,EGFR,ZD 4190,ErbB-1,HER1,ZD-4190,ZD4190
- 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]-
- ZD-4190;ZD 4190;ZD4190
- ZD-4190