KDU691
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- CAS号:
- 1513879-19-0
- 英文名:
- KDU691
- 英文别名:
- KDU691;KDU691 >=98% (HPLC);KDU691;KDU-691;KDU 691;1513879-19-0;Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-;PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
- 中文名:
- KDU691
- 中文别名:
- 化合物KDU691;N-(4-氯苯基)-N-甲基-3-(4-(甲基氨基甲酰基)苯基)咪唑并[1,2-A]吡嗪-6-甲酰胺
- CBNumber:
- CB33384777
- 分子式:
- C22H18ClN5O2
- 分子量:
- 419.86
- MOL File:
- 1513879-19-0.mol
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KDU691化学性质
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密度:
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1.35±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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14.59±0.46(Predicted)
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颜色:
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White to off-white
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KDU691性质、用途与生产工艺
KDU691是疟原虫PI4K特异性抑制剂，对其休眠子形式和肝内裂殖体的IC50值分别为0.18 μM和0.061 μM。
During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691.
KDU691
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-12912 | KDU691
KDU691 | 1513879-19-0 | 5mg | 1245元 |
| 2024/08/19 | HY-12912 | KDU691
KDU691 | 1513879-19-0 | 10mM * 1mLin DMSO | 1369元 |
1513879-19-0, KDU691 相关搜索:
- 抗疟配体
- N-(4-氯苯基)-N-甲基-3-(4-(甲基氨基甲酰基)苯基)咪唑并[1,2-A]吡嗪-6-甲酰胺
- 化合物KDU691
- 1513879-19-0
- PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
- Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-
- KDU691 >=98% (HPLC)
- KDU691;KDU-691;KDU 691;1513879-19-0
- KDU691