Gefitinib-based PROTAC 3
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- CAS号:
- 2230821-27-7
- 英文名:
- Gefitinib-based PROTAC 3
- 英文别名:
- NTN21277;Gefitinib-PROTAC-3;Gefitinib-based PROTAC 3;NTN21277(Gefitinib-based PROTAC 3);Gefitinib-based PROTAC 3,Epidermal growth factor receptor,inhibit,Inhibitor,Gefitinib based PROTAC 3,HER1,PROTACs,ErbB-1,Gefitinibbased PROTAC 3,EGFR;(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- 中文名:
- Gefitinib-based PROTAC 3
- 中文别名:
- 基于吉非替尼的PROTAC?3;吉非替尼-PROTAC-3(吉非替尼杂质54);化合物GEFITINIB-BASED PROTAC 3;1-{2-[3-(2-{5-[4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-基氧基]戊基氧基}乙氧基)-丙酰基氨基]-(S)-3,3-二甲基-丁酰基}-(2S,4R)-4-羟基吡咯烷-2-甲酰基 4-(4-甲基噻唑-5-基)苯甲胺;(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-氯-4-氟苯基)氨基)-7-甲氧基喹唑啉-6-基)氧基)戊基)氧基)乙氧基)丙酰胺基)-3,3-二甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺
- CBNumber:
- CB34667936
- 分子式:
- C47H57ClFN7O8S
- 分子量:
- 934.52
- MOL File:
- 2230821-27-7.mol
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Gefitinib-based PROTAC 3化学性质
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沸点:
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1065.6±65.0 °C(Predicted)
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密度:
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1.300±0.06 g/cm3(Predicted)
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储存条件:
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4°C, away from moisture and light
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溶解度:
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DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 16 mg/ml; Ethanol: 10 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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14.07±0.40(Predicted)
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颜色:
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Off-white to light yellow
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Gefitinib-based PROTAC 3性质、用途与生产工艺
Gefitinib-based PROTAC 3 通过连接器将EGFR结合元件与VHL配体偶联，可诱导 EGFR 及其突变体的降解，在HCC827(第19外显子)和H3255(L858R)中的DC50值分别为11.7 nM和22.3 nM。
| Target | Value |
EGFR
(in HCC827(Exon 19 del) cells)
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11.7 nM(DC50)
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EGFR
(in H3255 (L858R) cells)
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22.3 nM(DC50)
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用途
可通过linker将EGFR结合元件与VHL配体结合，作用于HCC827和H3255细胞，诱导EGFR降解，DC50分别为11.7nM 和22.3nM。
Gefitinib-based PROTAC 3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2025/02/08 | HY-123921 | Gefitinib-based PROTAC 3 | 2230821-27-7 | 1 mg | 480元 |
| 2025/02/08 | HY-123921 | Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3 | 2230821-27-7 | 5mg | 1200元 |
Gefitinib-based PROTAC 3
生产厂家
2230821-27-7, Gefitinib-based PROTAC 3 相关搜索:
- 抑制剂
- 配体家族
- C47H57ClFN7O8S
- 吉非替尼-PROTAC-3(吉非替尼杂质54)
- (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-氯-4-氟苯基)氨基)-7-甲氧基喹唑啉-6-基)氧基)戊基)氧基)乙氧基)丙酰胺基)-3,3-二甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺
- 基于吉非替尼的PROTAC?3
- 化合物GEFITINIB-BASED PROTAC 3
- 1-{2-[3-(2-{5-[4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-基氧基]戊基氧基}乙氧基)-丙酰基氨基]-(S)-3,3-二甲基-丁酰基}-(2S,4R)-4-羟基吡咯烷-2-甲酰基 4-(4-甲基噻唑-5-基)苯甲胺
- 2230821-27-7
- (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- Gefitinib-based PROTAC 3,Epidermal growth factor receptor,inhibit,Inhibitor,Gefitinib based PROTAC 3,HER1,PROTACs,ErbB-1,Gefitinibbased PROTAC 3,EGFR
- Gefitinib-PROTAC-3
- NTN21277(Gefitinib-based PROTAC 3)
- NTN21277
- Gefitinib-based PROTAC 3