Alamandine
|
|
|
- CAS号:
- 1176306-10-7
- 英文名:
- Alamandine
- 英文别名:
- Alamandine;Angiotensin A (1-7);L-Proline, L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-;Angiotensin A (1-7) trifluoroacetate salt H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt
- 中文名:
- Alamandine
- 中文别名:
- CBNumber:
- CB34668988
- 分子式:
- C40H62N12O9
- 分子量:
- 855
- MOL File:
- 1176306-10-7.mol
|
|
|
Alamandine化学性质
-
密度:
-
1.42±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
3.28±0.20(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
Alamandine性质、用途与生产工艺
Alamandine 是一种血管活性肽，是肾素-血管紧张素系统 (RAS) 的成员，还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。
Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood.
Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling.
Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes.
Alamandine (0.15 μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide.
|
Animal Model:
|
Male spontaneously hypertensive rats (SHRs, 50-week-old)
|
|
Dosage:
|
0.15 μL/h (~50 μg/kg/day)
|
|
Administration:
|
Administered by mini-osmotic pumps; for 6 weeks
|
|
Result:
|
Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function.
|
Alamandine
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-P3108 | Alamandine | | 1 mg | 1727元 |
| 2024/08/19 | HY-P3108 | Alamandine
Alamandine | 1176306-10-7 | 5mg | 3800元 |
1176306-10-7, Alamandine 相关搜索:
- 多肽
- 1176306-10-7
- L-Proline, L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-
- Angiotensin A (1-7) trifluoroacetate salt H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt
- Angiotensin A (1-7)
- Alamandine