1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-

CAS号:: 1446350-60-2

英文名:: 1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-

英文别名:: rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate;Proteasome,tau,trypsin-like,20S,TCH165,IDPs,chymotrypsin-like,degradation,TCH 165,α-syn,inhibit,caspase-like,TCH-165,assembly,Inhibitor;1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-

中文名:: 1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-

中文别名:: 化合物TCH-165;REL-(4R,5R)-1-苄基-5-(4-(苄基氨基)苯基)-2-(4-甲氧基苯基)-4-苯基-4,5-二氢-1H-咪唑-4-羧酸乙酯

CBNumber:: CB35562371

分子式:: C39H37N3O3

分子量:: 595.73

MOL File:: 1446350-60-2.mol

化学性质安全信息用途供应商 22

1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-化学性质

沸点:: 724.6±70.0 °C(Predicted)

密度:: 1.14±0.1 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: DMSO: 250 mg/mL (419.65 mM)

酸度系数(pKa):: 7.15±0.70(Predicted)

形态:: Solid

颜色:: Light yellow to yellow

安全信息

1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-性质、用途与生产工艺

生物活性

TCH-165 是蛋白酶体组装的小分子调节剂，可增加 20S 水平并促进 20S 介导的蛋白质降解。

TCH-165 (0.01-10 μM; 72 hours; RPMI8226 and U87MG cells) treatment inhibits cell growth of RPMI8226 and U87MG cells with IC50 of 1.6 μM and 2.4 μM, respectively.
TCH-165 (0-10 μM; 24 hours; HEK293T cells) treatment enhances ODC degradation is blocked by BTZ indicated that this event is proteasome-mediated. TCH-165 enhances proteolytic degradation in a concentration-dependent manner.
TCH-165 enhances the chymotrypsin-like (CT-L), trypsin-like (Tryp-L) and caspase-like (Casp-L) activities with EC ₅₀ s of 4.2 μM, 3.2 μM and 4.7 μM, respectively.
TCH-165 enhances 20S-mediated degradation of IDPs, α-syn, and tau in vitro, and does not induce the degradation of structured proteins such as GAPDH.
TCH-165-treated cells display a decrease in the assembled 26S and an increase in the 20S proteasome. TCH-165 regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation.

Cell Viability Assay

Cell Line:	RPMI8226 and U87MG cells
Concentration:	0.01-10 μM
Incubation Time:	72 hours
Result:	Inhibited cell growth of RPMI8226 and U87MG cells with IC ₅₀ of 1.6 μM and 2.4 μM, respectively.

Western Blot Analysis

Cell Line:	HEK293T cells
Concentration:	0 μM, 3 μM, 10 μM
Incubation Time:	24 hours
Result:	Enhanced proteolytic degradation in a concentration-dependent manner.

1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel- 上下游产品信息

上游原料

下游产品

1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel- 生产厂家

全球有 22家供应商 1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
上海海皋科技有限公司	021-57646680 18306277365	sunkai@chembiobanksh.com	中国	2043	55
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9707	58
上海瀚香生物科技有限公司	17754423994 17754423994	2853530910@QQ.com	中国	8011	62
上海芮晖化工科技有限公司	21-31433387 15618786686	sales@rechemscience.com	中国	2973	58
上海超岚化工科技中心	QQ:65489617 15618227136	info@SuperLan-chem.com	中国	9929	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	中国	6313	58
上海源溪生物科技有限公司	021-58447131 13564518121	sales@dcchemicals.com	中国	9412	58
常州辰鸿生物科技有限公司	0519-85788828 13775037613	sales@chemrenpharm.com	中国	3600	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29778	58
武汉沃格达生物科技有限公司	15071299552	262933239@qq.com	中国	6641	58
上海毕得医药科技股份有限公司	400-1647117 15221909166	product02@bidepharm.com	中国	63720	58
江苏药恒医药科技有限公司	13524761129	2183470029@qq.com	中国	864	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	23963	58
河南阿尔法化工有限公司	0371-55013243 15324716602	2853979810@qq.com	中国	10010	58
安徽行舟医药科技有限公司	17755122868 17755122868	2049639868@qq.com	中国	9807	58
南京世洲生物科技有限公司	025-85560043 15850508050	cindy.huang@synzest.com	中国	12007	58
上海杰瑞兴生物医药科技有限公司	17721492509	643638326@qq.com	中国	5347	58
銳迪國際科技有限公司	18024082417	market@ubiochem.com	中国	9274	58

1446350-60-2, 1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel- 相关搜索:

抑制剂
C39H37N3O3
REL-(4R,5R)-1-苄基-5-(4-(苄基氨基)苯基)-2-(4-甲氧基苯基)-4-苯基-4,5-二氢-1H-咪唑-4-羧酸乙酯
化合物TCH-165
1446350-60-2
Proteasome,tau,trypsin-like,20S,TCH165,IDPs,chymotrypsin-like,degradation,TCH 165,α-syn,inhibit,caspase-like,TCH-165,assembly,Inhibitor
rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate
1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-