Tat-NR2Baa
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- CAS号:
- 847829-41-8
- 英文名:
- Tat-NR2Baa
- 英文别名:
- Tat-NR2Baa;L-Alanine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-α-glutamyl-L-alanyl-L-α-aspartyl-
- 中文名:
- Tat-NR2Baa
- 中文别名:
- TAT-NR2B9C对照多肽;H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-LYS-LEU-SER-SER-ILE-GLU-ALA-ASP-ALA-OH
- CBNumber:
- CB36185221
- 分子式:
- C103H184N42O29
- 分子量:
- 2474.87
- MOL File:
- 847829-41-8.mol
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Tat-NR2Baa化学性质
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密度:
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1.52±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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形态:
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Solid
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颜色:
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White to off-white
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Tat-NR2Baa性质、用途与生产工艺
Tat-NR2BAA 是 Tat-NR2B9c (HY-P0117) 的对照肽 (control peptide)，没有活性。Tat-NR2BAA 的序列与 Tat-NR2B9c 相似，但在 COOH 末端 tSXV 基序中有一个双点突变，这使得它无法结合 PSD-95。Tat-NR2B9c 是一种可通透细胞膜的多肽，破坏 PSD-95/NMDAR 的结合。
Tat-NR2BAA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue. Tat-NR2Baa (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell. But Tat-NR2Baa has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c (HY-P0117).Tat-NR2Baa (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons.
Tat-NR2Baa
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-P2307 | Tat-NR2Baa
Tat-NR2Baa | 847829-41-8 | 1mg | 2200元 |
| 2024/04/30 | HY-P2307 | Tat-NR2Baa
Tat-NR2Baa | 847829-41-8 | 5mg | 5500元 |
847829-41-8, Tat-NR2Baa 相关搜索:
- 目录肽
- C103H184N42O29
- TAT-NR2B9C对照多肽
- H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-LYS-LEU-SER-SER-ILE-GLU-ALA-ASP-ALA-OH
- 847829-41-8
- L-Alanine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-α-glutamyl-L-alanyl-L-α-aspartyl-
- Tat-NR2Baa