化合物AY 9944
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- CAS号:
- 366-93-8
- 英文名:
- AY 9944
- 英文别名:
- AY 9944;trans-id;AY99442HCl;AY 9944 dihydrochlor;AY 9944 DIHYDROCHLORIDE;AY 9944 - CAS 366-93-8 - Calbiochem;TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL;1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride;trans1,4-bis(2-dichlorobenzylaminoethyl)cyclohexanedichlorhydrate
- 中文名:
- 化合物AY 9944
- 中文别名:
- 化合物AY 9944;反式-1,1'-(环己烷-1,4-二基)双(N-(2-氯苄基)甲胺)二盐酸盐
- CBNumber:
- CB3673047
- 分子式:
- C22H30Cl4N2
- 分子量:
- 464.3
- MOL File:
- 366-93-8.mol
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化合物AY 9944化学性质
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熔点:
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288-293.5 °C(lit.)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 14 mg/mL
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形态:
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White solid
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颜色:
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white
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水溶解性:
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Soluble to 50 mM in water
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敏感性:
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Hygroscopic
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化合物AY 9944性质、用途与生产工艺
AY 9944 是一种特异的胆固醇生物合成 (cholesterol biosynthesis) 抑制剂。AY 9944 抑制 7- 脱氢胆固醇 Δ7- 还原酶 (DHCR7) 酶 (IC50=13 nM)。AY 9944 引起胆固醇不足和 7DHC 积累。在高剂量下，AY 9944 也可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶，这会导致胆固醇 8-en-3β-ol 的积累。
用途
Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol Δ9-reductase and Δ9,7-sterol isomerase. A sonic hedgehog inhibitor.
类别
有毒物品
毒性分级
高毒
急性毒性
口服-小鼠 LD50: 155 毫克/公斤
可燃性危险特性
可燃; 燃烧产生有毒氮氧化物和氯化物烟雾; 它能抑制体内胆固醇合成
储运特性
库房通风低温干燥; 与食品原料分开存放
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
化合物AY 9944
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-107420 | AY 9944 | | 1 mg | 454元 |
| 2024/08/19 | HY-107420 | AY 9944 | 366-93-8 | 5mg | 1000元 |
366-93-8, 化合物AY 9944 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Lipid signaling
- C22H30Cl4N2
- C22H28Cl2N22HCl
- 反式-1,1'-(环己烷-1,4-二基)双(N-(2-氯苄基)甲胺)二盐酸盐
- 化合物AY 9944
- 366-93-8
- trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride
- 7DHC,AY 9944,hypocholesterolemia,inhibit,AY-9944,cholesterol,Inhibitor,isomerase,AY9944,Δ7-Δ8,accumulation,reductase,biosynthesis
- AY 9944 dihydrochlor
- AY 9944 - CAS 366-93-8 - Calbiochem
- AY 9944 DIHYDROCHLORIDE
- AY 9944
- TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL
- TRANS-1,4-BIS(2-CHLOROBENZYLAMINOETHYL) CYCLOHEXANE DIHYDROCHLORIDE
- TRANS-N,N-BIS[2-CHLOROPHENYLMETHYL]-1,4-CYCLOHEXANEDIMETHANAMINE DIHYDROCHLORIDE
- trans-n,n’-bis(2-chlorobenzyl)-1,4-cyclohexanebis(methylamine)dihydrochlorid
- trans-n,n’-(1,4-cyclohexylenedimethylene)bis(2-chlorobenzylamine)dihydrochlo
- trans-id
- trans1,4-bis(2-dichlorobenzylaminoethyl)cyclohexanedichlorhydrate
- (2-chlorobenzyl)-[[4-[[(2-chlorobenzyl)amino]methyl]cyclohexyl]methyl]amine dihydrochloride
- trans-1,4-Bis(2-Chlorobenzylamimomethyl)cyclohexane dihydrochloride
- trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride
- N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride
- trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane,dihydrochloride
- AY99442HCl
- 1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE
- 1,1'-((1r,4r)-cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine)
- N-[(2-chlorophenyl)methyl]-1-[4-[[(2-chlorophenyl)methylamino]methyl]cyclohexyl]methanamine dihydrochloride
- trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride
- 4-cyclohexanedimethanamine,n,n’-bis((2-chlorophenyl)methyl)-dihydrochlor
- 4-cyclohexanebis(methylamine),n,n’-bis(o-chlorobenzyl)-dihydrochloride
- 1,4-cyclohexanebis(methylamine),n,n’-bis(2-chlorobenzyl)-,dihydrochloride,(e