甘珀酸钠
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- CAS号:
- 7421-40-1
- 英文名:
- Carbenoxolone disodium
- 英文别名:
- neogel;sanodin;duogastrone;pyrogastrone;20-beta)-3-bet;ulcus-tablinen;sodiumcarbenoxolone;CARBENOXOLONE SODIUM;Carbenoxalone Sodium;Carbenoxolone disodi
- 中文名:
- 甘珀酸钠
- 中文别名:
- 甘珀酸钠;卡柏若克索龙;甘珀酸 二钠盐;氢琥珀酸甘草次酸;氢琥珀酸甘草次酸二钠盐;18Β-甘草次酸半琥珀酸酯二钠;18β-甘草次酸半琥珀酸酯二钠
- CBNumber:
- CB3680281
- 分子式:
- C34H48Na2O7
- 分子量:
- 614.72
- MOL File:
- 7421-40-1.mol
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甘珀酸钠化学性质
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熔点:
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>275°C (dec.)
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储存条件:
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2-8°C
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溶解度:
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Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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pKa1 4.18; pKa2 5.52(at 25℃)
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颜色:
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White to Off-White
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水溶解性:
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Soluble in water to 100 mM.
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稳定性:
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Hygroscopic
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LogP:
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7.083 (est)
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CAS 数据库:
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7421-40-1(CAS DataBase Reference)
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甘珀酸钠性质、用途与生产工艺
Carbenoxolone disodium 是甘草酸 (HY-N0184) 的活性代谢物和人 11β-HSD 和细菌 3α, 20β-HSD 的抑制剂。Carbenoxolone disodium 是一种缝隙连接的解耦剂 (gap junctions) 和并且可以有效抑制牛痘病毒生长。Carbenoxolone disodium 可用于研究消化性、食道和口腔溃疡和炎症的相关研究。
IC50: human 11β-HSD; bacterial 3α, 20β-HSD; gap junction;
Vaccinia
virus
Carbenoxolone disodium (6-150 μM; pre-treatment 1 hour) inhibits
Vaccinia
virus (VACV) replication in a gap junction-independent in HaCaT cells, and it has toxicity effects on VACV-A5L-EGFP infected cells at 48 h.Carbenoxolone (30 μM; pre-treatment 1 hour) does not upregulate PP2A expression, but induces the late protein A27 expression in hacat cells.
Cell Viability Assay
Cell Line:
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HaCaT cells
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Concentration:
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6 μM, 12 μM, 30 μM, 60 μM, 150 μM
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Incubation Time:
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Pre-treatment 1 hour
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Result:
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Had no toxicity until 48 hours at high dose in virus-infected cells.
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Western Blot Analysis
Cell Line:
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HaCaT cells
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Concentration:
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30 μM
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Incubation Time:
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Pre-treatment 1 hour
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Result:
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Presented an obvious upregulation of A27.
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Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Diazepam) does not induce a muscle relaxant activity and shows muscle relaxant activity compared to normal saline, and this effect was more than diazepam in the traction test.Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Pentylenetetrazole) significantly increases sleeping time and decreases latency in mice as a dose-dependent manner in Pentylenetetrazole (PTZ) Seizure model. The ED
50
value is 83.3 mg/kg (%95 CL:556.29).
Animal Model:
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Male BALB/c mice
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Dosage:
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100, 200 and 300 mg/kg
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Administration:
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Intraperitoneal injection; 30, 60 and 60 min before Pentylenetetrazole
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Result:
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Significantly increased the sleeping time in mice.
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类别
有毒物质
毒性分级
中毒
急性毒性
口服-大鼠 LD50: 2450 毫克/公斤; 腹腔-小鼠 LD50: 120 毫克/公斤
可燃性危险特性
热分解排出有毒氧化钠烟雾
储运特性
库房低温通风干燥
灭火剂
水, 二氧化碳, 泡沫, 干粉
甘珀酸钠
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-B1367 | Carbenoxolone disodium | | 5 mg | 225元 |
2024/04/30 | HY-B1367 | 甘珀酸钠 Carbenoxolone disodium | 7421-40-1 | 25mg | 684元 |
甘珀酸钠
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甘珀酸钠国内生产厂家
7421-40-1, 甘珀酸钠 相关搜索:
- Miscellaneous
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- 中药对照品
- 标准品
- 小分子抑制剂
- Chiral Building Blocks
- Asymmetric Synthesis
- Complex Molecules
- C34H48Na2O7
- 18Β-甘草次酸半琥珀酸酯二钠
- 18β-甘草次酸半琥珀酸酯二钠
- 氢琥珀酸甘草次酸二钠盐
- 卡柏若克索龙
- 氢琥珀酸甘草次酸
- 甘珀酸 二钠盐
- 甘珀酸钠
- 7421-40-1
- (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-((3-carboxypropanoyl)oxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid, sodium salt
- Carbenoxolonedisodium,(3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oicaciddisodium
- Carbenoxolone disodi
- Carbenoxolone disodium USP/EP/BP
- DISODIUM 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-OLEAN-12-EN-29-OIC ACID
- Carbenoxolone disodium
(YP 003 disodium)
- Carbenoxolone (sodium salt)
- Disodium (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10-(4-oxido-4-oxobutanoyl)oxy-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
- Carbenoxolone disodiuM salt >=98%
- (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oicaciddisodium
- 3β-(3-Carboxypropionyloxy)-11-oxoolean-12-en-30-oic acid disodium salt
- 18β-Glycyrrhetinic acid hydrogen succinate disodium salt
- (20S)-3β-[(3-Carboxypropanoyl)oxy]-11-oxoolean-12-en-29-oic acid disodium salt
- disodium 4-(20-carboxylato-11-oxo-30-beta-norolean-12-en-3-yloxy)-4-oxobutyrate
- carbenoxolone disodium
- Carbenoxalone Sodium
- 3-Hydroxy-11-oxoolean-12-en-30-oic Acid Hydrogen Succinate Disodium Salt
- (3,20)-3-(3-Carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic Acid
- Carbenoxolone sodium [USAN:JAN]
- 3β-hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate
- ulcus-tablinen
- sodiumcarbenoxolone
- sodium3-beta-hydroxy-11-oxo-12-oleanen-30-oatesodiumsuccinate
- sanodin
- pyrogastrone
- olean-12-en-30-oicacid,3-beta-hydroxy-11-oxo-,hydrogensuccinate,disodiums
- olean-12-en-29-oicacid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,disodiumsalt,(
- neogel
- glycyrrhetinicacidhydrogensuccinate,disodiumsalt
- duogastrone
- disodiumglycyrrhetinylsuccina
- 3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium
- 3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal
- 20-beta)-3-bet