CS-1506
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- CAS号:
- 210345-04-3
- 英文名:
- Z-LEHD-FMK
- 英文别名:
- CS-1506;abs813893;Z-LEHD-FMK;CASPASE-9 INHIBITOR;Z-LE(OME)HD(OME)-FMK;CASPASE-9 INHIBITOR I;Z-LEHD-FLUOROMETHYLKETONE;Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK;Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE;Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
- 中文名:
- CS-1506
- 中文别名:
- CBNumber:
- CB3758272
- 分子式:
- C32H43FN6O10
- 分子量:
- 690.73
- MOL File:
- Mol file
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CS-1506化学性质
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沸点:
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1008.2±65.0 °C(Predicted)
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密度:
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1.272±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO.
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形态:
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powder
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酸度系数(pKa):
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11.11±0.46(Predicted)
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颜色:
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White to yellow
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CS-1506性质、用途与生产工艺
Z-LEHD-FMK 是一种选择性和不可逆的 caspase-9 抑制剂，可防止致命的再灌注损伤并减弱细胞凋亡。Z-LEHD-FMK 在大鼠脊髓损伤模型中也表现出神经保护作用。
Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.
Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.
Apoptosis Analysis
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Cell Line:
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SW480, H460, HCT116 and 293 cells
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Concentration:
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20 μM
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Incubation Time:
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Pretreated for 30 min
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Result:
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Protected HCT116 and 293 cells from TRAIL-induced apoptosis.
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Western Blot Analysis
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Cell Line:
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HCT116, SW480 cells
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Concentration:
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20 μM
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Incubation Time:
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2 h
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Result:
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Protected procaspase 3 from cleavage in HCT116 cells but not in SW480 cells, especially at the 16-h time point.
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Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.
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Animal Model:
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Male Wistar albino rats (250-350 g) with SCI
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Dosage:
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0.8 μmol/kg
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Administration:
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I.v. for 1 or 7 days
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Result:
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Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.
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CS-1506
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-P1010 | CS-1506
Z-LEHD-FMK | 210345-04-3 | 1mg | 2500元 |
| 2024/04/30 | HY-P1010 | Z-LEHD-FMK | | 5 mg | 7500元 |
210345-04-3, CS-1506 相关搜索:
- Caspase/Related Products
- Caspases/Apoptosis
- \t抑制剂
- 生化试剂
- C32H43FN6O10
- C32H42FN6O10
- 210345-04-3
- Z-LEHD-FMK，Z-Leu-Glu(OMe)-His-Asp(OMe)-CH?F
- Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
- abs813893
- L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
- CS-1506
- Z-LE(OME)HD(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
- Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate
- Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK
- Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
- Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
- Z-LE(OME)HD(OME)-FMK
- Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE
- Z-LEHD-FMK
- Z-LEHD-FLUOROMETHYLKETONE
- CASPASE-9 INHIBITOR I
- CASPASE-9 INHIBITOR (FLUOROMETHYLKETONE)
- CASPASE-9 INHIBITOR
- BENZYLOXYCARBONYL-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE