CS-1506
|
|
- CAS号:
- 210345-04-3
- 英文名:
- Z-LEHD-FMK
- 英文别名:
- CS-1506;abs813893;Z-LEHD-FMK;CASPASE-9 INHIBITOR;Z-LE(OME)HD(OME)-FMK;CASPASE-9 INHIBITOR I;Z-LEHD-FLUOROMETHYLKETONE;Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK;Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE;Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
- 中文名:
- CS-1506
- 中文别名:
- 多肽Z-LEHD-FMK
- CBNumber:
- CB3758272
- 分子式:
- C32H43FN6O10
- 分子量:
- 690.73
- MOL File:
- Mol file
|
|
|
CS-1506化学性质
-
沸点:
-
1008.2±65.0 °C(Predicted)
-
|
-
密度:
-
1.272±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
-20°C
-
|
-
溶解度:
-
Soluble in DMSO.
-
|
-
形态:
-
powder
-
|
-
酸度系数(pKa):
-
11.11±0.46(Predicted)
-
|
-
颜色:
-
White to yellow
-
|
CS-1506性质、用途与生产工艺
Z-LEHD-FMK 是一种选择性和不可逆的 caspase-9 抑制剂,可防止致命的再灌注损伤并减弱细胞凋亡。Z-LEHD-FMK 在大鼠脊髓损伤模型中也表现出神经保护作用。
Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.
Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.
Apoptosis Analysis
Cell Line:
|
SW480, H460, HCT116 and 293 cells
|
Concentration:
|
20 μM
|
Incubation Time:
|
Pretreated for 30 min
|
Result:
|
Protected HCT116 and 293 cells from TRAIL-induced apoptosis.
|
Western Blot Analysis
Cell Line:
|
HCT116, SW480 cells
|
Concentration:
|
20 μM
|
Incubation Time:
|
2 h
|
Result:
|
Protected procaspase 3 from cleavage in HCT116 cells but not in SW480 cells, especially at the 16-h time point.
|
Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.
Animal Model:
|
Male Wistar albino rats (250-350 g) with SCI
|
Dosage:
|
0.8 μmol/kg
|
Administration:
|
I.v. for 1 or 7 days
|
Result:
|
Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.
|
CS-1506
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-P1010 | CS-1506 Z-LEHD-FMK | 210345-04-3 | 1mg | 2500元 |
2024/08/19 | HY-P1010 | Z-LEHD-FMK | | 5 mg | 7500元 |
210345-04-3, CS-1506 相关搜索:
- Caspase/Related Products
- Caspases/Apoptosis
- 抑制剂
- \t抑制剂
- 生化试剂
- C32H43FN6O10
- C32H42FN6O10
- 多肽Z-LEHD-FMK
- 210345-04-3
- Z-LEHD-FMK,Z-Leu-Glu(OMe)-His-Asp(OMe)-CH?F
- Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
- abs813893
- L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
- CS-1506
- Z-LE(OME)HD(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK; Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
- Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate
- Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK
- Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
- Z-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
- Z-LE(OME)HD(OME)-FMK
- Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE
- Z-LEHD-FMK
- Z-LEHD-FLUOROMETHYLKETONE
- CASPASE-9 INHIBITOR I
- CASPASE-9 INHIBITOR (FLUOROMETHYLKETONE)
- CASPASE-9 INHIBITOR
- BENZYLOXYCARBONYL-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE