网站主页 >> CAS数据库列表 >> 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-
2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-
|
|
- CAS号:
- 2437547-04-9
- 英文名:
- 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-
- 英文别名:
- CCR-6 inhibitor 1,CCR6 inhibitor 1;2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-
- 中文名:
- 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-
- 中文别名:
- 化合物 T10715
- CBNumber:
- CB38206490
- 分子式:
- C24H23F3N4O3S
- 分子量:
- 504.52
- MOL File:
- 2437547-04-9.mol
|
|
|
2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-化学性质
-
沸点:
-
705.4±60.0 °C(Predicted)
-
|
-
密度:
-
1.391±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : ≥ 125 mg/mL (247.76 mM)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
14.71±0.50(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-性质、用途与生产工艺
CCR6 inhibitor 1 是一种有效、选择性的 CCR6 抑制剂,对猴子和人 CCR6 的 IC50 值分别为 0.45 和 6 nM,对其选择性远高于人 CCR1 (IC50,> 30000 nM) 和 CCR7 (IC50,9400 nM)。CCR6 inhibitor 1 显著抑制 ERK 磷酸化。可用于自身免疫病和癌症的研究。
Moneky CCR6
0.45 nM (IC
50
)
|
Human CCR6
6 nM (IC
50
)
|
Human CCR7
9400 nM (IC
50
)
|
CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration.
2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-
上下游产品信息
上游原料
下游产品
2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-
生产厂家
2437547-04-9, 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]- 相关搜索:
- 化合物 T10715
- 2437547-04-9
- CCR-6 inhibitor 1,CCR6 inhibitor 1
- 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-