化合物 T12434
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- CAS号:
- 2070009-55-9
- 英文名:
- Benzamide, N-[(1S)-2-[4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl]-1-[[[2-(dimethylamino)acetyl]amino]methyl]ethyl]-3-chloro-4-(1-methylethoxy)-
- 英文别名:
- Benzamide, N-[(1S)-2-[4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl]-1-[[[2-(dimethylamino)acetyl]amino]methyl]ethyl]-3-chloro-4-(1-methylethoxy)-
- 中文名:
- 化合物 T12434
- 中文别名:
- 化合物 T12434
- CBNumber:
- CB38252174
- 分子式:
- C29H36ClN5O4
- 分子量:
- 554.08
- MOL File:
- 2070009-55-9.mol
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化合物 T12434化学性质
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密度:
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1.22±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 32 mg/mL (57.75 mM)
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形态:
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Solid
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酸度系数(pKa):
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13.32±0.46(Predicted)
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颜色:
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White to off-white
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化合物 T12434性质、用途与生产工艺
PF-2771 是一种选择性的着丝粒蛋白 E (CENP-E) 抑制剂，IC50 值为 16.1 nM，具有抗肿瘤活性。
PF-2771 is a potent and selective CENP-E inhibitor, inhibiting CENP-E motor activity with an IC
50
of 16.1 nM. PF-2771 shows no inhibitory effect on the ATPase activities of highly related kinesins (0% inhibition of Eg5/KSP, chromokinesin, and MCAK at both 1 or 10 μM PF-2771). PF-2771 exhibits inactive activity against 74 protein kinases (all < 23% inhibition with 1 μM PF-2771, < 40% with 10 μM PF-2771). PF-2771 is cytotoxic to the basal-like breast cancer tumor cell survival, with EC
50
s of < 0.1 μM, and with no cytotoxicity on the normal and premalignant cell lines (EC
50
> 5 μM). PF-2771 (100 nM) reusults in a chromosomal congression defect in MDA-MB-468 cells.
PF-2771 (100 mg/kg, every day i.p.) potently inhibits CENP-E motor function, and causes tumor regression in SCID mice bearing AA1077 mammary tumors.
化合物 T12434
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2070009-55-9, 化合物 T12434 相关搜索:
- C29H36ClN5O4
- 化合物 T12434
- 2070009-55-9
- Benzamide, N-[(1S)-2-[4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl]-1-[[[2-(dimethylamino)acetyl]amino]methyl]ethyl]-3-chloro-4-(1-methylethoxy)-