Duocarmycin DM
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- CAS号:
- 英文名:
- Duocarmycin DM
- 英文别名:
- Duocarmycin DM
- 中文名:
- 中文别名:
- CBNumber:
- CB39041494
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
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Duocarmycin DM性质、用途与生产工艺
Duocarmycin DM 是一种 DNA 小沟烷基化剂 (DNA minor-groove alkylator)，是一种抗体药物结合物 (ADCs) 毒素。Duocarmycin DM 因特有的结构而具有抗癌活性。
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Daunorubicins/Doxorubicins
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The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from
Streptomyces sp.
that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture.
Duocarmycin DM shows cytotoxicity to several human cancer cells, with IC
50
of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively.
Duocarmycin DM
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