Disitertide TFA
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- CAS号:
- 英文名:
- Disitertide TFA
- 英文别名:
- Disitertide TFA
- 中文名:
- 中文别名:
- CBNumber:
- CB39041616
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
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Disitertide TFA化学性质
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形态:
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Solid
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颜色:
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Off-white to light yellow
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Disitertide TFA性质、用途与生产工艺
Disitertide (P144) TFA 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide (P144) TFA 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines.
Western Blot Analysis
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Cell Line:
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Mouse embryo osteoblast precursor MC3T3-E1 cells.
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Concentration:
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100 μg/mL.
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Incubation Time:
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4 h.
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Result:
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Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.
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Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.
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Animal Model:
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Human hypertrophic scars were implanted in 60 nude mice.
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Dosage:
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300 μg/mL was added the Lipogel.
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Administration:
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Topical application daily administered.
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Result:
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Successful shedding was achieved in 83,3% of the xenografts.
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Disitertide TFA
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Disitertide TFA 试剂级价格
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2022/09/18 | HY-P0118A | Disitertide TFA | | 5mg | 3500元 |
| 2022/09/18 | HY-P0118A | Disitertide TFA | | 10 mg | 5600元 |