盐酸氟西汀杂质
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- CAS号:
- 3545-67-3
- 英文名:
- N4-(7-chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
- 英文别名:
- NSC14050;NSC 14050;NSC-14050;Aralen HCl;Unii-nt0J0815S5;Chloroquine HCl;Einecs 222-592-1;Aralen hydrochloride;Chloroquine dihydrochloride;4-((4-Amino-1-methylbutyl)amino)-7-chloroquinoline dihydrochloride
- 中文名:
- 盐酸氟西汀杂质
- 中文别名:
- 盐酸氯喹;二盐酸盐氯喹;二盐酸氯奎因杂质;化合物 T0194L2
- CBNumber:
- CB3929733
- 分子式:
- C18H28Cl3N3
- 分子量:
- 392.79402
- MOL File:
- 3545-67-3.mol
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盐酸氟西汀杂质性质、用途与生产工艺
Chloroquine dihydrochloride 是一种广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。Chloroquine dihydrochloride 是autophagy 和toll-like receptors (TLRs) 的抑制剂。Chloroquine dihydrochloride 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50=1.13 μM)。
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HIV-1
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Malaria
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TLRs
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SARS-COV-2
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Chloroquine dihydrochloride (20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine dihydrochloride (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells[1]. Chloroquine dihydrochloride (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine dihydrochloride has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression. TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly reduces HuH7 cell proliferation in vitro.
Chloroquine dihydrochloride (0.01-100 μM; 48 hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV-2) at low-micromolar concentration (EC50=1.13 μM). Chloroquine dihydrochloride blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.
Chloroquine dihydrochloride (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model.
TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine.
盐酸氟西汀杂质
上下游产品信息
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-17589B | 盐酸氟西汀杂质
Chloroquine dihydrochloride | | 50 mg | 500元 |
3545-67-3, 盐酸氟西汀杂质 相关搜索:
- 盐酸氯喹
- 二盐酸盐氯喹
- 化合物 T0194L2
- 二盐酸氯奎因杂质
- 3545-67-3
- N4-(7-chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
- 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine,dihydrochloride
- Aralen HCl
- NSC 14050
- NSC14050
- NSC-14050
- Unii-nt0J0815S5
- Quinoline, 4-((4-amino-1-methylbutyl)amino)-7-chloro-, dihydrochloride
- Einecs 222-592-1
- Chloroquine HCl
- Chloroquine dihydrochloride
- Aralen hydrochloride
- 4-((4-Amino-1-methylbutyl)amino)-7-chloroquinoline dihydrochloride
- 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, dihydrochloride (9ci)