150779-71-8
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- CAS号:
- 150779-71-8
- 英文名:
- SDZ 281 977
- 英文别名:
- SDZ-LAP 977;SDZ 281 977;SDZ281 977,SDZ-281-977,SDZ281977;Benzoic acid, 5-[2-(2,5-dimethoxyphenyl)ethyl]-2-hydroxy-, methyl ester
- 中文名:
- 150779-71-8
- 中文别名:
- 化合物 T16866
- CBNumber:
- CB41381076
- 分子式:
- C18H20O5
- 分子量:
- 316.35
- MOL File:
- 150779-71-8.mol
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150779-71-8化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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颜色:
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White to off-white
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150779-71-8性质、用途与生产工艺
SDZ 281-977 是 EGF 受体酪氨酸激酶抑制剂 Lavendustin A 的衍生物。
The anticancer profile of SDZ 281-977 is investigated in nude mice bearing the human tumor cell lines A431 (vulvar carcinoma cells), MIA PaCa-2 (pancreatic tumor cells) and MDA-MB-231 (breast carcinoma cells). These cell lines are selected because of their sensitivity for SDZ 281-977. The IC
50
values for inhibition of growth of A431, MIA PaCa-2 and MDA-MB-231 cells are 0.21 μM, 0.29 μM and 0.43 μM, respectively.
Nude mice bearing A431 human vulvar carcinomas receive intravenous injections of SDZ 281-977 (1-10 mg/kg) for 4 weeks. This treatment results in a dose-dependent inhibition of tumor growth. Orally administered SDZ 281-977 (30 mg/kg) induces a 54% inhibition of A431 tumor growth after 3 weeks of treatment. The above regimens are well tolerated. No significant change in body weight occurred during treatment.
150779-71-8
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101756 | SDZ281-977 | | 1 mg | 1363元 |
| 2024/04/30 | HY-101756 | SDZ281-977 | | 5 mg | 3000元 |
150779-71-8, 150779-71-8 相关搜索:
- 化合物 T16866
- 150779-71-8
- SDZ281 977,SDZ-281-977,SDZ281977
- Benzoic acid, 5-[2-(2,5-dimethoxyphenyl)ethyl]-2-hydroxy-, methyl ester
- SDZ-LAP 977
- SDZ 281 977