218791-21-0
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- CAS号:
- 218791-21-0
- 英文名:
- IMISOPASEM MANGANESE
- 英文别名:
- CG4419;CG 4419;M-40403;SC72325;CG-4419;SC-72325;SC 72325;IMISOPASEM MANGANESE;Imisopasem manganese(m40403);Imisopasem manganese (M-40403, GC-4419)
- 中文名:
- 218791-21-0
- 中文别名:
- 伊米帕锰
- CBNumber:
- CB41509117
- 分子式:
- C21H35N5.Cl2Mn
- 分子量:
- 483.387
- MOL File:
- 218791-21-0.mol
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218791-21-0化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO:5.0(Max Conc. mg/mL);10.34(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);6.21(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);41.38(Max Conc. mM)
PBS (pH 7.2):3.0(Max Conc. mg/mL);6.21(Max Conc. mM)
Water:16.0(Max Conc. mg/mL);33.1(Max Conc. mM)-
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形态:
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A crystalline solid
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颜色:
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White to off-white
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218791-21-0性质、用途与生产工艺
Imisopasem manganese (M40403)是稳定的MnSOD的非肽基模拟物。
M40403 is a small molecule, synthetic manganese containing superoxide dismutase mimetic (SODm) that removes superoxide anions without interfering with other reactive species known to be involved in inflammatory responses (e.g. nitric oxide, NO and peroxynitrite, ONOO-).
M40403 is a small-molecule superoxide dismutase mimetic that has shown efficacy in animal model disease states in which superoxide anions are thought to play a key role. M40403 inhibits the inflammatory response following the intrapleural injection of carrageenan in rats. All parameters of inflammation are attenuated by M40403 except for NOx, PGE2 and IL-10 which remains unaltered. Decreased apoptosis of the large and particularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in the M40403 pre-treated mice. M40403 is effective in reducing TBI-induced tissue destruction and has potential as a new radioprotective agent.
218791-21-0
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13336 | 218791-21-0
Imisopasem manganese | 218791-21-0 | 2mg | 990元 |
| 2024/04/30 | HY-13336 | 218791-21-0
Imisopasem manganese | 218791-21-0 | 5mg | 1700元 |
218791-21-0, 218791-21-0 相关搜索:
- 伊米帕锰
- 218791-21-0
- Imisopasem manganese (M-40403, GC-4419)
- SC-72325
- SC72325
- SC 72325
- M40403; M 40403; M-40403; CG4419; CG 4419; CG-4419; SC72325; SC-72325; SC 72325; IMISOPASEM MANGANESE
- CG-4419
- CG4419
- CG 4419
- Imisopasem manganese(m40403)
- M-40403
- IMISOPASEM MANGANESE