Isofagomine D-Tartrate
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- CAS号:
- 957230-65-8
- 英文名:
- Isofagomine D-Tartrate
- 英文别名:
- Isofagomine tartrate;Isofagomine D-Tartrate;D-Isofagomine D-Tartrate;Afegostat DTartrate,Afegostat D Tartrate;Afegostat D-Tartrate (D-Isofagomine (D-Tartrate);Afegostat D-Tartrate (Synonyms: D-Isofagomine (D-Tartrate);(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate
- 中文名:
- Isofagomine D-Tartrate
- 中文别名:
- 化合物 T19182;阿戈司他 D-酒石酸盐
- CBNumber:
- CB41873108
- 分子式:
- C10H19NO9
- 分子量:
- 297.26
- MOL File:
- 957230-65-8.mol
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Isofagomine D-Tartrate化学性质
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熔点:
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124-126°C
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储存条件:
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-20°C Freezer, Under Inert Atmosphere
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溶解度:
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Soluble in DMSO (up to 2 mg/ml)
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形态:
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solid
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颜色:
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Off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Isofagomine D-Tartrate性质、用途与生产工艺
Afegostat D-Tartrate 是一种药理学伴侣，高亲和力且特异性和可逆地结合内质网 (ER) 中的酸性 β-葡萄糖苷酶 (GCase)。
Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.
Isofagomine D-Tartrate
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Isofagomine D-Tartrate
生产厂家
957230-65-8, Isofagomine D-Tartrate 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Chiral Reagents
- 制剂-抑制剂
- 化合物 T19182
- 阿戈司他 D-酒石酸盐
- 957230-65-8
- Afegostat DTartrate,Afegostat D Tartrate
- Isofagomine tartrate
- D-Isofagomine D-Tartrate
- Afegostat D-Tartrate (D-Isofagomine (D-Tartrate)
- Afegostat D-Tartrate (Synonyms: D-Isofagomine (D-Tartrate)
- Isofagomine D-Tartrate
- (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate