BIX 01294
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- CAS号:
- 935693-62-2
- 英文名:
- BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
- 英文别名:
- CS-207;BIX 01294;BIX01294,BIX-01294;BIX 01294 (free base);EZSolution? BIX 01294;BIX-01294;BIX 01294; BIX01294;BIX 01294 hydrate trihydrochloride;Histone Lysine methyltransferase Inhibitor;Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem;N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine
- 中文名:
- BIX 01294
- 中文别名:
- BIX01294游离;BIX 01294 三盐酸盐 水合物;BIX-01294,G9A和G9A样蛋白组蛋白甲基转移酶抑制剂;N-(1-苄基哌啶-4-基)-6,7-二甲氧基-2-(4-甲基-1,4-二氮杂卓-1-基)喹唑啉-4-胺;N-(1-苄基哌啶-4-基)-6,7-二甲氧基-2-(4-甲基-1,4-二氮杂环庚-1-基)喹唑啉-4-胺;2-(六氢-4-甲基-1H-1,4-二氮杂卓-1-基)-6,7-二甲氧基-N-[1-(苯基甲基)-4-哌啶基]-4-喹唑啉胺;BIX 01294,2-(六氢-4-甲基-1H-1,4-二氮杂-1-基)-6,7-二甲氧基-N-[1-(苯基甲基)-4-哌啶基]-4-喹唑啉胺水合三盐酸盐;2-(HEXAHYDRO-4-METHYL-1H-1,4-DIAZEPIN-1-YL)-6,7-DIMETHOXY-N-[1-(PHENYLMETHYL)-4-PIPERIDINYL]-4-QUINAZOLINAMINE 三盐酸盐 水合物
- CBNumber:
- CB42095439
- 分子式:
- C28H38N6O2
- 分子量:
- 490.64
- MOL File:
- 935693-62-2.mol
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BIX 01294化学性质
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沸点:
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654.6±65.0 °C(Predicted)
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密度:
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1.195±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
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酸度系数(pKa):
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9.34±0.70(Predicted)
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形态:
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Off-white solid
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颜色:
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Off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
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InChIKey:
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BZOWJAYUMMHCDW-UHFFFAOYSA-N
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BIX 01294性质、用途与生产工艺
BIX-01294 是一种 G9a 组蛋白甲基转移酶 (G9a Histone Methyltransferase) 抑制剂，IC50 值为 1.9 μM。
IC50: 1.9 μM (G9a Histone Methyltransferase)
BIX-01294 (4.1 μM) treatment of G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes.
BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy.
BIX-01294 (1 µg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.
BIX 01294
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | 46783 | BIX-01294, 95%
BIX-01294, 95% | 935693-62-2 | 100mg | 3930元 |
| 2024/11/08 | HY-10587 | BIX-01294 | | 1 mg | 327元 |
935693-62-2, BIX 01294 相关搜索:
- G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor.
- Epigenetics
- 抑制剂
- 合成有机化合物配体
- 信号转导通路激酶抑制剂
- 细胞周期
- C28H43Cl3N6O3
- C28H38N6O2
- C28H38N6O23HCl
- C28H41Cl3N6O2
- BIX-01294,G9A和G9A样蛋白组蛋白甲基转移酶抑制剂
- N-(1-苄基哌啶-4-基)-6,7-二甲氧基-2-(4-甲基-1,4-二氮杂卓-1-基)喹唑啉-4-胺
- BIX 01294,2-(六氢-4-甲基-1H-1,4-二氮杂-1-基)-6,7-二甲氧基-N-[1-(苯基甲基)-4-哌啶基]-4-喹唑啉胺水合三盐酸盐
- BIX01294游离
- N-(1-苄基哌啶-4-基)-6,7-二甲氧基-2-(4-甲基-1,4-二氮杂环庚-1-基)喹唑啉-4-胺
- BIX 01294 三盐酸盐 水合物
- 2-(HEXAHYDRO-4-METHYL-1H-1,4-DIAZEPIN-1-YL)-6,7-DIMETHOXY-N-[1-(PHENYLMETHYL)-4-PIPERIDINYL]-4-QUINAZOLINAMINE 三盐酸盐 水合物
- 2-(六氢-4-甲基-1H-1,4-二氮杂卓-1-基)-6,7-二甲氧基-N-[1-(苯基甲基)-4-哌啶基]-4-喹唑啉胺
- 935693-62-2
- 2-(Hexahydro-4-Methyl-1H-1,4-Diazaze-1-Yl)-6,7-Dimethoxy-N-[1-(Phenylmethyl)-4-Piperidyl]-4-Quinazoline Amine
- EZSolution? BIX 01294
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quina
- N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine
- Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem
- CS-207
- BIX01294,BIX-01294
- N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trih
- BIX-01294;BIX 01294; BIX01294
- Histone Lysine methyltransferase Inhibitor
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine
- BIX 01294 (free base)
- 2-(Hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-4-quinazolinaMine hydrate trihydrochloride
- 4-QuinazolinaMine, 2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-
- BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
- BIX 01294 hydrate trihydrochloride
- BIX 01294
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride