网站主页 >> CAS数据库列表 >> (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
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- CAS号:
- 230961-21-4
- 英文名:
- (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
- 英文别名:
- UK 370106;UK 370106,UK370106;(R)-3-((S)-1-((S)-2-Methoxy-1-phenylethylaMino)-3,3-diMethyl-1-o;(R)-3-(((S)-1-(((S)-2-Methoxy-1-phenylethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-(2-m;(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid;(3R)-3-[[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid;(βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoicacid;[1,1'-Biphenyl]-4-hexanoic acid, β-[[[(1S)-1-[[[(1S)-2-methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-, (βR)-
- 中文名:
- (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
- 中文别名:
- 化合物 T13249;化合物 UK-370106
- CBNumber:
- CB42514857
- 分子式:
- C35H44N2O5
- 分子量:
- 572.73
- MOL File:
- 230961-21-4.mol
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(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid化学性质
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熔点:
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178-180 °C
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沸点:
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802.7±65.0 °C(Predicted)
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密度:
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1.122±0.06 g/cm3(Predicted)
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储存条件:
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Store at +4°C
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溶解度:
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<57.27mg/ml in DMSO; <14.32mg/ml in ethanol
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形态:
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solid
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酸度系数(pKa):
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4.68±0.10(Predicted)
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颜色:
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White
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(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid性质、用途与生产工艺
UK-370106 是一种有效且高度选择性的 MMP-3 (IC50 为 23 nM) 和 MMP-12 (IC50 为 42 nM) 抑制剂，效力比 MMP-1，MMP-2，MMP-9 和 MMP-14 高 1200 倍以上，比 MMP-13 高约 100 倍。UK-370106 有效抑制 MMP-3 对 [3H]-fibronectin 的裂解 (IC50 为 320 nM)，并且对角质形成细胞迁移影响很小。
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MMP-3
23 nM (IC
50
)
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MMP-12
42 nM (IC
50
)
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MMP-8
1.75 μM (IC
50
)
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MMP-13
2.3 μM (IC
50
)
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MMP-7
5.8 μM (IC
50
)
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MMP-9
30.4 μM (IC
50
)
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MMP-2
34.2 μM (IC
50
)
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MMP-14
66.9 μM (IC
50
)
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The potency of UK-370106 (compound 7) for the inhibition of MMP-13 is 2.3 µM, some 100-fold less potent than its inhibition of MMP-3. UK-370106 is found to be inactive (IC
50
> 100 µM) vs zinc metalloproteases PCP and TACE and possesses the following inhibitory potencies vs MMP-2 (IC
50
of 34.2 µM), MMP-7 (IC
50
of 5.8 µM), MMP-8 (IC
50
of 1.75 µM), MMP-9 (IC
50
of 30.4 µM) and MMP-14 (IC
50
of 66.9 µM).
UK-370106 potently inhibits cleavage of [
3
H]-fibronectin by MMP-3 (IC
50
of 320 nM) but does not inhibit cleavage of [
3
H]-gelatin by either MMP-2 or -9 up to the highest concentration tested (100 µM).
UK-370106 is not cytotoxic to, nor affected proliferation of, fibroblasts, keratinocytes, or endothelial cells at 50-100 µM in vitro.
Following iv (rat; 2 mg/kg) or topical administration to dermal wounds (rabbit), UK-370106 (compound 7) is cleared rapidly (t
1/2
= 23 min) from plasma, but slowly (t
1/2
approximately 3 days) from dermal tissue. In a model of chronic dermal ulcers, topical administration of UK-370106 for 6 days substantially inhibits MMP-3 ex vivo.
(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-107639 | (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
UK-370106 | 230961-21-4 | 1mg | 1950元 |
| 2024/08/19 | HY-107639 | (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
UK-370106 | 230961-21-4 | 5mg | 5800元 |
(R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid
生产厂家
230961-21-4, (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid 相关搜索:
- 抑制剂
- C35H44N2O5
- 化合物 UK-370106
- 化合物 T13249
- 230961-21-4
- UK 370106,UK370106
- [1,1'-Biphenyl]-4-hexanoic acid, β-[[[(1S)-1-[[[(1S)-2-methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-, (βR)-
- (3R)-3-[[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid
- (R)-3-(((S)-1-(((S)-2-Methoxy-1-phenylethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-(2-m
- (R)-3-((S)-1-((S)-2-Methoxy-1-phenylethylaMino)-3,3-diMethyl-1-o
- UK 370106
- (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoicacid
- (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid