THIARABINE
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- CAS号:
- 26599-17-7
- 英文名:
- THIARABINE
- 英文别名:
- OSI-7836;THIARABINE;4'-thioarabinoCytidine;OSI-7836 (4'-thio-araC, T-araC);4-Amino-1-(4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone;4-Amino-1-(4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone;2(1H)-Pyrimidinone, 4-amino-1-(4-thio-β-D-arabinofuranosyl)-;4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one
- 中文名:
- THIARABINE
- 中文别名:
- 蒂亚萨宾;化合物 T17071;4-氨基-1-(4-硫代-Β-D-阿糖腺苷)-2(氢)-嘧啶酮;4-氨基-1-(4-硫代-Β-D-阿糖腺苷)-2(氢)-嘧啶酮
- CBNumber:
- CB42668460
- 分子式:
- C9H13N3O4S
- 分子量:
- 259.28
- MOL File:
- 26599-17-7.mol
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THIARABINE化学性质
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沸点:
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535.0±60.0 °C(Predicted)
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密度:
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1.90±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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13.41±0.70(Predicted)
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颜色:
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White to off-white
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THIARABINE性质、用途与生产工艺
Thiarabine (OSI-7836) 具有抗肿瘤活性，能抑制 DNA 的合成。
Thiarabine has demonstrated exceptional antitumor activity against numerous human tumor xenografts in mice, being superior to gemcitabine, clofarabine, or cytarabine. Unlike cytarabine, Thiarabine demonstrates excellent activity against solid tumor xenografts, suggesting that this agent has the kind of robust activity in animal models that leads to clinical utility. Thiarabine is effective orally (bioavailability of approximately 16%) and with once per day dosing: Two characteristics that distinguish it from cytarabine. Although both the structure and basic mechanism of action of Thiarabine are similar to that of cytarabine, there are many quantitative differences in the biochemical pharmacology of these two agents that can explain the superior antitumor activity of Thiarabine. Two important attributes are the long retention time of the 5'-triphosphate of thiarabine in tumor cells and its potent inhibition of DNA synthesis. The biochemical pharmacology of Thiarabine is also different from that of gemcitabine.
THIARABINE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16496 | Thiarabine | | 1 mg | 2000元 |
| 2022/09/18 | HY-16496 | THIARABINE
Thiarabine | 26599-17-7 | 5mg | 6800元 |
26599-17-7, THIARABINE 相关搜索:
- 标准品
- 6599-17-7
- 化合物 T17071
- 4-氨基-1-(4-硫代-Β-D-阿糖腺苷)-2(氢)-嘧啶酮
- 4-氨基-1-(4-硫代-Β-D-阿糖腺苷)-2(氢)-嘧啶酮
- 蒂亚萨宾
- 26599-17-7
- 4'-thioarabinoCytidine
- 4-Amino-1-(4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone
- 2(1H)-Pyrimidinone, 4-amino-1-(4-thio-β-D-arabinofuranosyl)-
- OSI-7836
- 4-Amino-1-(4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone
- 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one
- OSI-7836 (4'-thio-araC, T-araC)
- THIARABINE