盐酸水苏碱 化学药品说明书益母草流浸膏—盐酸水苏碱的测定—薄层扫描法|药物分析方法信息
Intervention of Stachydrine significantly suppresses the level of p-IκB (ser32) protein in the cytosol and NF-κB (p65) protein in the nucleus (P<0.05). Treatment with Stachydrine hydrochloride (50 µM, 200 µM, 500 µM and 1000 µM) noticeably inhibited MCF-7 and T47D cell proliferation in dose- and time-dependent manner. High concentrations (500 µM and 1000 µM) of Stachydrine significantly increased the frequency of both studied cell lines at the G1 phase of cell cycle, suggesting that Stachydrine hydrochloride could cause cell cycle arrest.